Full Product Name
Nr5a1 Antibody - C-terminal region
Product Gene Name
anti-NR5A1 antibody
[Similar Products]
Product Synonym Gene Name
Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1; SF1[Similar Products]
Antibody/Peptide Pairs
Nr5a1 peptide (MBS3228575) is used for blocking the activity of Nr5a1 antibody (MBS3203607)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: VADQMTLLQN CWSELLVLDH IYRQVQYGKE DSILLVTGQE VELSTVAVQA
3D Structure
ModBase 3D Structure for P33242
Species Reactivity
Cow, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 79%; Guinea Pig: 93%; Horse: 86%; Human: 86%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Sheep: 79%
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Nr5a1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-NR5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NR5A1 antibody
This is a rabbit polyclonal antibody against Nr5a1. It was validated on Western Blot
Target Description: Nr5a1 is a transcriptional activator. It seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. It binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Nr5a1 also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Nr5a1 binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Nr5a1 is activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Product Categories/Family for anti-NR5A1 antibody
Polyclonal; Transcription Factor; Cancer; Developmental Biology; Disease Related; DNA/RNA/Protein Interactions;
Applications Tested/Suitable for anti-NR5A1 antibody
Western Blot (WB)
Western Blot (WB) of anti-NR5A1 antibody
Host: Rabbit
Target Name: Nr5a1
Sample Type: Mouse Lung lysates
Antibody Dilution: 1.0ug/ml
NCBI/Uniprot data below describe general gene information for NR5A1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_620639
[Other Products]
NCBI GenBank Nucleotide #
NM_139051
[Other Products]
UniProt Primary Accession #
P33242
[Other Products]
UniProt Related Accession #
P33242[Other Products]
NCBI Official Full Name
steroidogenic factor 1
NCBI Official Synonym Full Names
nuclear receptor subfamily 5, group A, member 1
NCBI Official Symbol
Nr5a1 [Similar Products]
NCBI Official Synonym Symbols
ELP; SF1; SF-1; Ad4BP; ELP-3; Ftzf1; STF-1; Ftz-F1
[Similar Products]
NCBI Protein Information
steroidogenic factor 1
UniProt Protein Name
Steroidogenic factor 1
UniProt Synonym Protein Names
Adrenal 4-binding protein; Embryonal LTR-binding protein; ELP; Embryonal long terminal repeat-binding protein; Fushi tarazu factor homolog 1; Nuclear receptor subfamily 5 group A member 1; Steroid hormone receptor Ad4BP; Steroid hydroxylase positive regulator
Protein Family
Steroidogenic factor
UniProt Gene Name
Nr5a1 [Similar Products]
UniProt Synonym Gene Names
Ftzf1; SF-1; STF-1; ELP [Similar Products]
UniProt Entry Name
STF1_MOUSE
Research Articles on NR5A1
1. ChIP-sequence/ChIP studies indicated that Ad4BP/SF-1 binds to the upstream region of Ccne1 (cyclin E1) gene during G1/S phase.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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