Cytochrome P450 26A1, Polyclonal Antibody

Anti -Cytochrome P450 26A1 (CYP26A1)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 10; NC_000010.10 (94833232..94837641). Location: 10q23-q24

Polyclonal

IgG

Rabbit

Recognizes human CYP26A1.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.2% BSA, 40% glycerol.

May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-CYP26A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Cytochrome P450 (P450 or CYP) enzymes, a superfamily of b-type heme-containing proteins found in organisms from all

Antibodies; Abs to Enzymes, Cytochrome

ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF)

Suitable for use in ELISA, Western Blot and Immunofluorescence.
Dilution: ELISA: 1:100,000 using 50-100ng control peptide per well
Western Blot: 1-10ug/ml using ECL technique

48,558 Da[Similar Products]

cytochrome P450, family 26, subfamily A, polypeptide 1

cytochrome P450 26A1; hP450RAI; OTTHUMP00000020102; OTTHUMP00000020103; cytochrome P450RAI; retinoic acid 4-hydroxylase; P450, retinoic acid-inactivating, 1; retinoic acid-metabolizing cytochrome; cytochrome P450 retinoic acid-inactivating 1; cytochrome P450, subfamily XXVIA, polypeptide 1

Cytochrome P450, family 26, subfamily A, polypeptide 1

Q5VXH9_HUMAN

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and ***** tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq]

CYP26A1: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. Belongs to the cytochrome P450 family.

Protein type: Oxidoreductase; Endoplasmic reticulum; Cofactor and Vitamin Metabolism - retinol; EC 1.14.-.-

Chromosomal Location of Human Ortholog: 10q23-q24

Cellular Component: endoplasmic reticulum membrane

Molecular Function: retinoic acid binding; iron ion binding; retinoic acid 4-hydroxylase activity; heme binding; oxygen binding

Biological Process: anterior/posterior pattern formation; retinoic acid receptor signaling pathway; negative regulation of retinoic acid receptor signaling pathway; central nervous system development; vitamin metabolic process; neural crest cell development; metabolic process; xenobiotic metabolic process

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