Product Name
intestinal cell (MAK-like) kinase (ICK), Polyclonal Antibody
Full Product Name
Rabbit anti-human intestinal cell (MAK-like) kinase polyclonal Antibody
Product Synonym Names
intestinal cell (MAK-like) kinase; ICK; ECO; KIAA0936; LCK2; MGC46090; MRK
Product Gene Name
anti-ICK antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48020
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ICK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ICK antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for ICK. It may not necessarily be applicable to this product.
NCBI Accession #
AAI36422.1
[Other Products]
UniProt Secondary Accession #
O75985; Q5THL2; Q8IYH8; Q9BX17; Q9NYX3; A7MD41[Other Products]
UniProt Related Accession #
Q9UPZ9[Other Products]
Molecular Weight
34,071 Da[Similar Products]
NCBI Official Full Name
Intestinal cell (MAK-like) kinase
NCBI Official Synonym Full Names
intestinal cell (MAK-like) kinase
NCBI Official Symbol
ICK [Similar Products]
NCBI Official Synonym Symbols
ECO; MRK; LCK2
[Similar Products]
NCBI Protein Information
serine/threonine-protein kinase ICK; hICK; MAK-related kinase; laryngeal cancer kinase 2; serine/threonine protein kinase
UniProt Protein Name
Serine/threonine-protein kinase ICK
UniProt Synonym Protein Names
Intestinal cell kinase; hICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
ICK [Similar Products]
UniProt Synonym Gene Names
KIAA0936; hICK; LCK2; MRK [Similar Products]
UniProt Entry Name
ICK_HUMAN
NCBI Summary for ICK
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for ICK
ICK: a CMGC kinase of the RCK family. May play a role in cardiac development. Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Also expressed in many cancer cell lines. Two alternatively spliced isoforms have been described.
Protein type: Kinase, protein; EC 2.7.11.22; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); CMGC group; RCK family
Chromosomal Location of Human Ortholog: 6p12.1
Cellular Component: nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; cyclin-dependent protein kinase activity; magnesium ion binding; ATP binding
Biological Process: regulation of cell cycle; multicellular organismal development; intraflagellar transport; cilium biogenesis; signal transduction; protein amino acid phosphorylation
Disease: Endocrine-cerebroosteodysplasia
Research Articles on ICK
1. In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
