Full Product Name
Rabbit 5-HT-2C Antibody
Product Gene Name
anti-5-HT-2C antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: X; NC_000023.10 (113818551..114144624). Location: Xq24
3D Structure
ModBase 3D Structure for P28335
Species Reactivity
Human, mouse, rat
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-5-HT-2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-5-HT-2C antibody
Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for 5-HT-2C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000859.1
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NCBI GenBank Nucleotide #
NM_000868.2
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UniProt Primary Accession #
P28335
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UniProt Secondary Accession #
Q5VUF8; Q9NP28; B1AMW4[Other Products]
UniProt Related Accession #
P28335[Other Products]
Molecular Weight
51,821 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 2C isoform a
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
NCBI Official Symbol
HTR2C [Similar Products]
NCBI Official Synonym Symbols
HTR1C; 5-HT2C; 5-HTR2C
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NCBI Protein Information
5-hydroxytryptamine receptor 2C; 5-HT1C; 5-HT-1C; 5-HT-2C; serotonin receptor 2C; serotonin 5-HT-2C receptor; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor-1c
UniProt Protein Name
5-hydroxytryptamine receptor 2C
UniProt Synonym Protein Names
5-hydroxytryptamine receptor 1C; 5-HT-1C; 5-HT1C; Serotonin receptor 2C
UniProt Gene Name
HTR2C [Similar Products]
UniProt Synonym Gene Names
HTR1C; 5-HT-2C; 5-HT2C; 5-HTR2C; 5-HT-1C; 5-HT1C [Similar Products]
UniProt Entry Name
5HT2C_HUMAN
NCBI Summary for 5-HT-2C
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for 5-HT-2C
5-HT(2C): a G-protein coupled receptor. One of several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Mediates its action by activating a phosphatidylinositol-calcium second messenger system.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: serotonin binding; serotonin receptor activity; 5-HT2 receptor activity; drug binding
Biological Process: response to drug; cGMP biosynthetic process; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); behavioral fear response; regulation of corticotropin-releasing hormone secretion; serotonin receptor, phospholipase C activating pathway; locomotory behavior; positive regulation of phosphatidylinositol biosynthetic process; cellular calcium ion homeostasis; synaptic transmission; regulation of neurological process; release of sequestered calcium ion into cytosol; regulation of appetite; positive regulation of fat cell differentiation; feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); serotonin receptor signaling pathway
Research Articles on 5-HT-2C
1. used the most updated and assessed bioinformatic tools to predict which variations can give rise to
biological effects among 2450 HTR2C SNPs; suggest 48 SNPs worth considering in future association studies in psychiatry, psychology and pharmacogenomics
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