Product Name
DIS3L2, cDNA Clone
Full Product Name
DIS3L2 cDNA Clone
Product Gene Name
DIS3L2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaacctcc ggtccctggg gacccacaga ggtgtgtctg ctgtggctgg tccacatgac attggtgctt cgccaggtga caaaaagtca aagaacaggt ccacacgagg gaagaaaaag agcatatttg aaacttacat gtccaaggag gatgtttcag aaggcttgaa gagaggaaca ctcatccagg gtgtattgag aattaatcca aagaagtttc atgaagcctt cattccttcc ccggatggtg atcgagacat ttttattgat ggggttgttg ctcgtaatag agccttaaat ggggatctgg tggtcgtgaa actgcttccc gaggagcatt ggaaggtagt taaaccagag agcaatgaca aagaaacaga agctgcgtat gaatcagata tccccgagga gctctgtgga caccatctcc cgcaacagtc cctgaaaagc tataatgaca gtcctgatgt cattgtagag gctcagtttg atggcagcga ctcagaagat ggacatggca tcacacaaaa tgtgctggtt gatggtgtta agaaactctc agtttgtgtt tctgagaaag gaagagagga tggtgatgca ccggttacaa aagatgagac cacctgcatt tcacaagaca caagagcttt atcggagaaa tccctgcaaa gatcagcaaa ggtggtttac atcttggaga aaaaacattc tcgagcagca accggcttcc tcaaactctt ggctgataag aacagcgaac tgtttaggaa atacgccctg ttttctccct cagaccaccg agtgcctaga atttatgtgc ctctcaagga ctgtccccag gactttgtgg cacggcctaa agattatgcc aacacactgt tcatctgccg cattgtggac tggaaggagg actgcaattt tgccctgggg cagctggcta agagtcttgg gcaggctggt gaaattgagc ctgaaacaga aggaatacta acagagtatg gcgtggattt ctctgatttc tcttcagaag ttctagaatg tcttcctcaa ggcctgccat ggacaattcc accagaggag ttcagcaaga gaagggattt aagaaaagac tgtatcttca ccattgaccc atcaaccgcc cgagacctcg atgatgccct ctcctgcaag ccactcgctg acggcaactt caaagtggga gttcacattg ctgacgtgag ttactttgtt ccggagggat ctgatctgga taaagtggct gccgagaggg ctacaagcgt ctacttggtt caaaaggtgg tccccatgct tcccaggctg ctgtgtgagg agctgtgcag cctcaacccc atgtccgaca agctgacctt ctctgtgatc tggacactga ctccagaggg caagatcctt gatgaatggt ttggccggac catcatccgc tcctgcacca aacttagcta cgagcatgca cagagcatga ttgaaagccc aactgagaaa atccctgcga aagagctgcc ccccatttcc ccagagcata gcagcgagga ggtacaccag gccgtcttga atctccacgg aattgccaag cagttacgcc agcagcgctt tgtggacggc gcacttcgtt tggatcagct aaagcttgct ttcactctgg accacgagac cggattgcct caaggatgtc atatctatga gtaccgcgag agcaacaagc cctgctgcgc cggcaccccc cgccccaaac aaggatgctc agtgacctgg tggaattctg cgaccagatg gggctgcccg tggacttcag ctccgcagga gccctcaata aaagcctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DIS3L2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DIS3L2. It may not necessarily be applicable to this product.
NCBI Accession #
BC036113
[Other Products]
UniProt Secondary Accession #
Q53S79; Q580W6; Q5XKH0; Q69YG5; Q6AW99; Q7Z4T6; Q8N9K9[Other Products]
UniProt Related Accession #
Q8IYB7[Other Products]
Molecular Weight
40,480 Da
NCBI Official Full Name
Homo sapiens DIS3 mitotic control homolog (S. cerevisiae)-like 2, mRNA
NCBI Official Synonym Full Names
DIS3 like 3'-5' exoribonuclease 2
NCBI Official Symbol
DIS3L2 [Similar Products]
NCBI Official Synonym Symbols
FAM6A; PRLMNS; hDIS3L2
[Similar Products]
NCBI Protein Information
DIS3-like exonuclease 2
UniProt Protein Name
DIS3-like exonuclease 2
Protein Family
DIS3-like exonuclease
UniProt Gene Name
DIS3L2 [Similar Products]
UniProt Synonym Gene Names
hDIS3L2 [Similar Products]
UniProt Entry Name
DI3L2_HUMAN
NCBI Summary for DIS3L2
The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012]
UniProt Comments for DIS3L2
DIS3L2: Ribonuclease that plays a critical role in RNA metabolism. It is essential for correct mitosis, and negatively regulates cell proliferation. Defects in DIS3L2 are the cause of Perlman syndrome (PRLMNS). An autosomal recessive congenital overgrowth syndrome. Affected children are large at birth, are hypotonic, and show organomegaly, characteristic facial dysmorphisms (inverted V-shaped upper lip, prominent forehead, deep-set eyes, broad and flat nasal bridge, and low-set ears), renal anomalies (nephromegaly and hydronephrosis), frequent neurodevelopmental delay, and high neonatal mortality. Perlman syndrome is associated with a high risk of Wilms tumor. Histologic examination of the kidneys in affected children shows frequent nephroblastomatosis, which is a precursor lesion for Wilms tumor. Belongs to the RNR ribonuclease family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor; Ribonuclease; EC 3.1.13.-
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: cytoplasm; nuclear exosome (RNase complex); polysome
Molecular Function: 3'-5'-exoribonuclease activity; magnesium ion binding; poly(U) binding; protein binding; ribonuclease activity
Biological Process: mitosis; mitotic sister chromatid separation; mRNA catabolic process, exonucleolytic; negative regulation of cell proliferation; rRNA catabolic process; rRNA processing; stem cell maintenance
Disease: Perlman Syndrome
Research Articles on DIS3L2
1. DIS3L2 interacts with Ago2 and governs target RNA-directed miRNA degradation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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