Product Name
Keratin 5 (KRT5), Recombinant Protein
Full Product Name
Recombinant Keratin 5 (KRT5)
Product Synonym Names
CK5; DDD; EBS2; K5; KRT5A; KRT5-A; Cytokeratin 5; 58 kDa cytokeratin; Type-II keratin Kb5; Epidermolysis Bullosa Simplex Dowling-Meara/Kobner/Weber-Cockayne Types
Product Gene Name
KRT5 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P13647
Purity/Purification
> 95%
Form/Format
Freeze-dried powder
Expression System
Prokaryotic expression
Buffer Formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Endotoxin Level
<1.0EU per 1ug (determined by the LAL method)
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Other Notes
Small volumes of KRT5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for KRT5 recombinant protein
Tumor immunity
Applications Tested/Suitable for KRT5 recombinant protein
Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
NCBI/Uniprot data below describe general gene information for KRT5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000415.2
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NCBI GenBank Nucleotide #
NM_000424.3
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UniProt Primary Accession #
P13647
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UniProt Secondary Accession #
Q6PI71; Q6UBJ0; Q8TA91[Other Products]
UniProt Related Accession #
P13647[Other Products]
Molecular Weight
Predicted Molecular Weight: 21.9kDa
NCBI Official Full Name
keratin, type II cytoskeletal 5
NCBI Official Synonym Full Names
keratin 5
NCBI Official Symbol
KRT5 [Similar Products]
NCBI Official Synonym Symbols
K5; CK5; DDD; DDD1; EBS2; KRT5A
[Similar Products]
NCBI Protein Information
keratin, type II cytoskeletal 5
UniProt Protein Name
Keratin, type II cytoskeletal 5
UniProt Synonym Protein Names
58 kDa cytokeratin; Cytokeratin-5; CK-5; Keratin-5; K5; Type-II keratin Kb5
UniProt Gene Name
KRT5 [Similar Products]
UniProt Synonym Gene Names
CK-5; K5 [Similar Products]
NCBI Summary for KRT5
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
UniProt Comments for KRT5
K5: Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP. Belongs to the intermediate filament family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cytoplasm; cytosol; extracellular exosome; intermediate filament; keratin filament; membrane; mitochondrion; nucleus; plasma membrane
Molecular Function: protein binding; structural constituent of cytoskeleton
Biological Process: cornification; cytoskeleton organization; epidermis development; hemidesmosome assembly; keratinization
Disease: Dowling-degos Disease 1; Epidermolysis Bullosa Simplex With Migratory Circinate Erythema; Epidermolysis Bullosa Simplex With Mottled Pigmentation; Epidermolysis Bullosa Simplex, Autosomal Recessive 1; Epidermolysis Bullosa Simplex, Dowling-meara Type; Epidermolysis Bullosa Simplex, Generalized; Epidermolysis Bullosa Simplex, Localized
Research Articles on KRT5
1. Dual small interfering RNA (siRNA) silencing of RARalpha and RARgamma reversed RA blockade of P4-induced CK5. Using promoter deletion analysis, we identified a region 1.1 kb upstream of the CK5 transcriptional start site that is necessary for P4 activation and contains a putative progesterone response element (PRE
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
