Product Name
SEMA3C, Polyclonal Antibody
Full Product Name
SEMA3C Antibody
Product Gene Name
anti-SEMA3C antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99985
Species Reactivity
Human, Mouse, Rat
Specificity
SEMA3C antibody detects endogenous levels of SEMA3C.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human SEMA3C.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-SEMA3C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SEMA3C antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-SEMA3C antibody
IHC: 1:50~1:100
ELISA: 1:10000
Immunohistochemistry (IHC) of anti-SEMA3C antibody
Immunohistochemistry analysis of SEMA3C antibody in paraffin-embedded human pancreas tissue.
NCBI/Uniprot data below describe general gene information for SEMA3C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006370.1
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NCBI GenBank Nucleotide #
NM_006379.4
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UniProt Primary Accession #
Q99985
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UniProt Secondary Accession #
B4DRL8[Other Products]
UniProt Related Accession #
Q99985[Other Products]
NCBI Official Full Name
semaphorin-3C isoform 2
NCBI Official Synonym Full Names
semaphorin 3C
NCBI Official Symbol
SEMA3C [Similar Products]
NCBI Official Synonym Symbols
SemE; SEMAE
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NCBI Protein Information
semaphorin-3C
UniProt Protein Name
Semaphorin-3C
UniProt Synonym Protein Names
Semaphorin-E; Sema E
Protein Family
Semaphorin
UniProt Gene Name
SEMA3C [Similar Products]
UniProt Synonym Gene Names
SEMAE; Sema E [Similar Products]
NCBI Summary for SEMA3C
This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
UniProt Comments for SEMA3C
Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance ().
Research Articles on SEMA3C
1. The exploratory genome-wide association studies confirmed APOE and identified the novel loci: rs2525776 near SEMA3C (P = 1 x 10(-8), OR = 3.3 [2.1-5.1]).
Precautions
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Disclaimer
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