Full Product Name
JAM3 Antibody, HRP conjugated
Product Synonym Names
Junctional adhesion molecule C; JAM-C; JAM-2; Junctional adhesion molecule 3; JAM-3; JAM3; ORF Names:UNQ859/PRO1868
Product Gene Name
anti-JAM3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BX67
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Junctional adhesion molecule C protein (119-235AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-JAM3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-JAM3 antibody
Participates in cell-cell adhesion. It is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.
Product Categories/Family for anti-JAM3 antibody
Cardiovascular; Tags & Cell Markers; Signal transduction
Applications Tested/Suitable for anti-JAM3 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for JAM3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001192258.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001205329.1
[Other Products]
UniProt Primary Accession #
Q9BX67
[Other Products]
UniProt Secondary Accession #
Q8WWL8; Q96FL1; B3KWG9[Other Products]
UniProt Related Accession #
Q9BX67[Other Products]
Molecular Weight
29,223 Da
NCBI Official Full Name
junctional adhesion molecule C isoform 2
NCBI Official Synonym Full Names
junctional adhesion molecule 3
NCBI Official Symbol
JAM3 [Similar Products]
NCBI Official Synonym Symbols
JAMC; JAM-2; JAM-3; JAM-C
[Similar Products]
NCBI Protein Information
junctional adhesion molecule C
UniProt Protein Name
Junctional adhesion molecule C
UniProt Synonym Protein Names
JAM-2; Junctional adhesion molecule 3; JAM-3
Protein Family
Junctional adhesion molecule
UniProt Gene Name
JAM3 [Similar Products]
UniProt Synonym Gene Names
JAM-C; JAM-3 [Similar Products]
NCBI Summary for JAM3
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
UniProt Comments for JAM3
Participates in cell-cell adhesion. It is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.
Research Articles on JAM3
1. JAM-C controls Src family kinase (SFK) activation in leukemic stem cells and leukemia-initiating cell activity with exacerbated SFK activation was uniquely found within the JAM-C-expressing leukemic stem cell compartment.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
