peroxisomal biogenesis factor 12, ELISA Kit

Mouse Peroxisome assembly protein 12 (PEX12) ELISA kit; PAF-3; peroxin 12; peroxisome assembly factor 3; peroxisome assembly protein 12; peroxisomal biogenesis factor 12

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of PEX12 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9324201 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the peroxisomal biogenesis factor 12 (PEX12) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PEX12. The ELISA analytical biochemical technique of the MBS9324201 kit is based on PEX12 antibody-PEX12 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PEX12 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PEX12. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

40,633 Da

peroxisomal biogenesis factor 12

peroxisome assembly protein 12; peroxin-12

Peroxisome assembly protein 12

PEX12_MOUSE

PEX12: Required for protein import into peroxisomes. Defects in PEX12 are the cause of peroxisome biogenesis disorder complementation group 3 (PBD-CG3). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum. The PBD group is genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Defects in PEX12 are a cause of Zellweger syndrome (ZWS). ZWS is a fatal peroxisome biogenesis disorder characterized by dysmorphic facial features, hepatomegaly, ocular abnormalities, renal cysts, hearing impairment, profound psychomotor retardation, severe hypotonia and neonatal seizures. Death occurs within the first year of life. Belongs to the pex2/pex10/pex12 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system

Cellular Component: peroxisomal membrane; integral to peroxisomal membrane; membrane; integral to membrane; peroxisome

Molecular Function: protein C-terminus binding; zinc ion binding; metal ion binding

Biological Process: protein transport; peroxisome organization and biogenesis; transport; protein targeting to peroxisome; protein import into peroxisome matrix

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