Full Product Name
DAZ2 Antibody
Product Synonym Names
Deleted in azoospermia protein 2; DAZ2
Product Gene Name
anti-DAZ2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13117
Purity/Purification
Antigen Affinity Purified
Immunogen
Recombinant human Deleted in azoospermia protein 2 protein (N-200AA)
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-133497
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-DAZ2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DAZ2 antibody
RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
Applications Tested/Suitable for anti-DAZ2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-DAZ2 antibody
Recommended dilution: IHC: 1:20-1:200
Immunohistochemistry (IHC) of anti-DAZ2 antibody
Immunohistochemistry of paraffin-embedded human testis tissue using MBS7044497 at dilution 1:100
Immunohistochemistry (IHC) of anti-DAZ2 antibody
Immunohistochemistry of paraffin-embedded human skin tissue using MBS7044497 at dilution 1:100
NCBI/Uniprot data below describe general gene information for DAZ2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001005785.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001005785.2
[Other Products]
UniProt Primary Accession #
Q13117
[Other Products]
UniProt Secondary Accession #
Q2KHN6; Q96P41; Q9NR91[Other Products]
UniProt Related Accession #
Q13117[Other Products]
Molecular Weight
60,411 Da
NCBI Official Full Name
deleted in azoospermia protein 2 isoform 2
NCBI Official Synonym Full Names
deleted in azoospermia 2
NCBI Official Symbol
DAZ2 [Similar Products]
NCBI Official Synonym Symbols
pDP1678
[Similar Products]
NCBI Protein Information
deleted in azoospermia protein 2
UniProt Protein Name
Deleted in azoospermia protein 2
Protein Family
Deleted in azoospermia protein
UniProt Gene Name
DAZ2 [Similar Products]
UniProt Entry Name
DAZ2_HUMAN
NCBI Summary for DAZ2
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for DAZ2
DAZ2: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Defects in DAZ2 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2). It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility. Belongs to the RRM DAZ family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: Yq11.223
Disease: Spermatogenic Failure, Y-linked, 2
Research Articles on DAZ2
1. Studies indicate that partial RNA-binding proteins DAZ1/2 deletion was associated wih male infertility, but partial RNA-binding proteins DAZ3/4 deletion was not associated with male infertility.
Precautions
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