Product Name
TBCE, cDNA Clone
Full Product Name
TBCE cDNA Clone
Product Gene Name
TBCE cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgagtgaca ctttgacagc ggatgtcatt ggtcgaagag ttgaagttaa tggagaacat gcaacagtac gttttgctgg tgttgtccct cccgtggcag gaccctggtt aggagtagaa tgggacaatc ccgagagagg aaagcatgat gggagccacg aagggactgt gtattttaaa tgcaggcacc cgacaggagg atcctttatt cgtccgaaca aggtaaattt tggaacagac tttcttactg caattaagaa ccgctatgtg ttagaagatg gaccagagga agatagaaaa gagcaaattg ttacaattgg aaataaacct gtggagacta tcggttttga ctctattatg aaacagcaaa gtcagctgag caagttgcaa gaagtttctc tgaggaactg tgcagtaagt tgtgctggtg aaaaaggagg agttgctgaa gcatgtccta atatcagaaa ggtagatttg tcaaaaaacc tgttgtcatc atgggatgaa gtgatacaca ttgctgatca gctcagacac ctggaagtcc ttaatgtcag tgaaaataaa ctaaaatttc cctccggttc agtattaact ggaacgcttt ctgtactgaa ggttttagtc ctcaatcaaa caggaataac gtgggctgag gtgctgcggt gtgtcgcggg gtgcccaggc ctggaggaac tctaccttga gtctaacaac attttcattt ccgaaaggcc aacagatgtt ctccagacag tcaagttatt agatctttcc tctaatcaat taattgatga aaatcagctg tatctgatag cccacctgcc caggttagaa caattaatcc tctctgacac tggaatttct tctctacatt ttccggatgc tggaattggg tgcaaaacgt ccatgttccc atccttgaag tacctggtag taaacgacaa tcagatatca caatggtcgt ttttcaatga gctagagaag ttaccaagtc tacgggcttt gtcctgccta agaaaccccc tgaccaaaga ggacaaagaa gcagagacgg cgcgactact cattatcgcc agcattggcc agctgaagac gctgaacaaa tgtgagattc tccccgagga gaggcggaga gctgagcttg actaccgaaa agcttttgga aatgagtgga aacaggctgg tggacataag gatccggaaa aaaacagact cagcgaagaa ttcctcacag cccatcccag ataccagttc ctctgcctga aatatggtgc acctgaagat tgggaactca aaacacagca accacttatg ctgaaaaacc agctactaac actgaagata aaataccctc atcaacttga tcagaaagtc ctggagaaac aactgccggg ctccatgaca attcaaaagg tgaagggatt gctgtcacgt cttctcaaag ttcctgtgtc agaccttctg ttgtcctatg aaagtcccaa aaagccgggc agagaaatcg agctggaaaa tgacctaaag tcattacagt tttattctgt ggaaaatgga gattgtctat tagtgcgatg gtga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TBCE cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TBCE. It may not necessarily be applicable to this product.
NCBI Accession #
BC008654
[Other Products]
UniProt Secondary Accession #
A8K8C2; B7Z3P1[Other Products]
UniProt Related Accession #
Q15813[Other Products]
Molecular Weight
64,852 Da
NCBI Official Full Name
Homo sapiens tubulin folding cofactor E, mRNA
NCBI Official Synonym Full Names
tubulin folding cofactor E
NCBI Official Symbol
TBCE [Similar Products]
NCBI Official Synonym Symbols
HRD; KCS; KCS1; pac2
[Similar Products]
NCBI Protein Information
tubulin-specific chaperone E
UniProt Protein Name
Tubulin-specific chaperone E
UniProt Synonym Protein Names
Tubulin-folding cofactor E
Protein Family
Tubulin-specific chaperone
UniProt Gene Name
TBCE [Similar Products]
UniProt Entry Name
TBCE_HUMAN
NCBI Summary for TBCE
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TBCE
TBCE: Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation. Defects in TBCE are a cause of hypoparathyroidism- retardation-dysmorphism syndrome (HRD); also known as hypoparathyroidism with short stature, mental retardation, and seizures or Sanjad-Sakati syndrome. HRD is an autosomal recessive disorder reported almost exclusively in Middle Eastern populations. Defects in TBCE are the cause of Kenny-Caffey syndrome type 1 (KCS1). KCS1 is similar to HRD with the additional features of osteosclerosis and recurrent bacterial infections. Belongs to the TBCE family.
Protein type: Chaperone
Chromosomal Location of Human Ortholog: 1q42.3
Cellular Component: microtubule
Molecular Function: chaperone binding
Biological Process: post-chaperonin tubulin folding pathway; protein folding
Disease: Hypoparathyroidism-retardation-dysmorphism Syndrome; Kenny-caffey Syndrome, Type 1
Research Articles on TBCE
1. Sanjad-Sakati syndrome molecular pathology has been shown to be due to mutations in the TBCE gene on chromosome 1q42-q43.
Precautions
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Disclaimer
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