Product Name
gephyrin (GPHN), Polyclonal Antibody
Full Product Name
gephyrin Rabbit Polyclonal
Product Gene Name
anti-GPHN antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-GPHN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GPHN antibody
ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
NCBI/Uniprot data below describe general gene information for GPHN. It may not necessarily be applicable to this product.
NCBI Accession #
AAF81785.1
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UniProt Secondary Accession #
Q96KU4; Q9H4E9; Q9P2G2[Other Products]
UniProt Related Accession #
Q9NQX3[Other Products]
Molecular Weight
83,448 Da[Similar Products]
NCBI Official Full Name
gephyrin
NCBI Official Synonym Full Names
gephyrin
NCBI Official Symbol
GPHN [Similar Products]
NCBI Official Synonym Symbols
GPH; GEPH; HKPX1; GPHRYN; MOCODC
[Similar Products]
NCBI Protein Information
gephyrin
UniProt Protein Name
Gephyrin
UniProt Synonym Protein Names
Domain E
UniProt Gene Name
GPHN [Similar Products]
UniProt Synonym Gene Names
MPT Mo-transferase [Similar Products]
UniProt Entry Name
GEPH_HUMAN
NCBI Summary for GPHN
This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq, Jul 2008]
UniProt Comments for GPHN
gephyrin: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. Homotrimer. Interacts with GABARAP. Inhibited by copper and tungsten. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; EC 2.7.7.75; EC 2.10.1.1
Chromosomal Location of Human Ortholog: 14q23.3
Cellular Component: cell junction; cytoplasm; cytoskeleton; dendrite; plasma membrane; postsynaptic membrane
Molecular Function: ATP binding; metal ion binding; protein binding
Biological Process: Mo-molybdopterin cofactor biosynthetic process; molybdenum incorporation into molybdenum-molybdopterin complex; molybdopterin cofactor biosynthetic process
Disease: Hyperekplexia, Hereditary 1; Molybdenum Cofactor Deficiency, Complementation Group C
Research Articles on GPHN
1. A yin-yang haplotype pattern encompassing gephyrin consists of 284 divergent nucleotide states and both variants vary drastically from their mutual ancestral haplotype, suggesting rapid evolution.
Precautions
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