VSX2, Polyclonal Antibody

Visual system homeobox 2; Ceh-10 homeodomain-containing homolog; Homeobox protein CHX10; VSX2; CHX10; HOX10

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This VSX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-291 amino acids from the C-terminal region of human VSX2.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.41 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-VSX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a homeobox protein originally described
as a retina-specific transcription factor. Mutations in this gene
are associated with microphthalmia, cataracts and iris
abnormalities.

Neuroscience

Western Blot (WB), ELISA (EIA)

WB~~1:1000

VSX2 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the VSX2 antibody detected the VSX2 protein (arrow).

39411

visual system homeobox 2

visual system homeobox 2

Visual system homeobox 2

CHX10; HOX10  [Similar Products]

VSX2_HUMAN

This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. [provided by RefSeq, Oct 2009]

CHX10: Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells. Defects in VSX2 are the cause of microphthalmia isolated type 2 (MCOP2); also known as isolated clinical anophthalmia. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present. Defects in VSX2 are the cause of microphthalmia with cataracts and iris abnormalities (MCOPCTI). Defects in VSX2 are the cause of microphthalmia isolated with coloboma type 3 (MCOPCB3); also known as isolated colobomatous microphthalmia 3. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Belongs to the paired homeobox family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: cytoplasm; nucleus

Molecular Function: sequence-specific DNA binding

Biological Process: negative regulation of cell proliferation; cell fate commitment; visual perception; transcription, DNA-dependent; response to stimulus; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; retinal bipolar neuron differentiation

Disease: Microphthalmia, Isolated 2; Microphthalmia, Isolated, With Coloboma 3

Gonzalez-Rodriguez, J., et al. Br J Ophthalmol 94(8):1100-1104(2010)
Iseri, S.U., et al. Hum. Genet. 128(1):51-60(2010)
Reichman, S., et al. Hum. Mol. Genet. 19(2):250-261(2010)
Nagel, S., et al. Mol. Cancer 9, 151 (2010) :
Zhang, X., et al. Mol. Vis. 15, 2911-2918 (2009) :

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