Product Name
Spermatid nuclear transition protein 1 (Tnp1), Recombinant Protein
Full Product Name
Recombinant Mouse Spermatid nuclear transition protein 1 (Tnp1)
Product Gene Name
Tnp1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-55@aa, Full Length of Mature Protein
Sequence
STSRKLKTHG MRRGKNRAPH KGVKRGGSKR KYRKSVLKSR KRGDDASRNY RSHL
3D Structure
ModBase 3D Structure for P10856
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Tnp1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Tnp1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_033433.1
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NCBI GenBank Nucleotide #
NM_009407.2
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UniProt Primary Accession #
P10856
[Other Products]
UniProt Related Accession #
P10856[Other Products]
Molecular Weight
6,407 Da
NCBI Official Full Name
spermatid nuclear transition protein 1
NCBI Official Synonym Full Names
transition protein 1
NCBI Official Symbol
Tnp1 [Similar Products]
NCBI Official Synonym Symbols
TP1; Tp-1; Stp-1
[Similar Products]
NCBI Protein Information
spermatid nuclear transition protein 1
UniProt Protein Name
Spermatid nuclear transition protein 1
Protein Family
Spermatid nuclear transition protein
UniProt Gene Name
Tnp1 [Similar Products]
UniProt Synonym Gene Names
STP-1; TP-1 [Similar Products]
UniProt Comments for Tnp1
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:10781074, PubMed:15163613, PubMed:15189834, PubMed:15083521, PubMed:28366643). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). The histone H2AFB1-HIST1H2BA/TH2B dimer is required for loading of TNP1 onto chromatin (PubMed:28366643).
Research Articles on Tnp1
1. JHDM2A directly binds to and controls the expression of transition nuclear protein 1 (Tnp1) and protamine 1 (Prm1) genes, the products of which are required for packaging and condensation of sperm chromatin
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
