Full Product Name
VSX2 Antibody
Product Synonym Names
VSX2; CHX10; Homeobox protein CHX10; MCOP2; MCOPCB3; RET1; HOX10; Visual system homeobox 2
Product Gene Name
anti-VSX2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P58304
Species Reactivity
Human, Mouse
Specificity
VSX2 Antibody detects endogenous levels of total VSX2
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human VSX2
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-VSX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-VSX2 antibody
Total protein Ab
Applications Tested/Suitable for anti-VSX2 antibody
Western Blot (WB)
Application Notes for anti-VSX2 antibody
Western Blot: 1:1000-3000
Western Blot (WB) of anti-VSX2 antibody
Western blot analysis VSX2 using NIH-3T3 whole cell lysates
NCBI/Uniprot data below describe general gene information for VSX2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_878314.1
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NCBI GenBank Nucleotide #
NM_182894.2
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UniProt Primary Accession #
P58304
[Other Products]
UniProt Secondary Accession #
A1A4X6[Other Products]
UniProt Related Accession #
P58304[Other Products]
Molecular Weight
39,411 Da
NCBI Official Full Name
visual system homeobox 2
NCBI Official Synonym Full Names
visual system homeobox 2
NCBI Official Symbol
VSX2 [Similar Products]
NCBI Official Synonym Symbols
RET1; CHX10; HOX10; MCOP2; MCOPCB3
[Similar Products]
NCBI Protein Information
visual system homeobox 2
UniProt Protein Name
Visual system homeobox 2
UniProt Synonym Protein Names
Ceh-10 homeodomain-containing homolog; Homeobox protein CHX10
Protein Family
Visual system homeobox
UniProt Gene Name
VSX2 [Similar Products]
UniProt Synonym Gene Names
CHX10; HOX10 [Similar Products]
UniProt Entry Name
VSX2_HUMAN
NCBI Summary for VSX2
This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. [provided by RefSeq, Oct 2009]
UniProt Comments for VSX2
CHX10: Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells. Defects in VSX2 are the cause of microphthalmia isolated type 2 (MCOP2); also known as isolated clinical anophthalmia. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present. Defects in VSX2 are the cause of microphthalmia with cataracts and iris abnormalities (MCOPCTI). Defects in VSX2 are the cause of microphthalmia isolated with coloboma type 3 (MCOPCB3); also known as isolated colobomatous microphthalmia 3. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Belongs to the paired homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 14q24.3
Disease: Microphthalmia, Isolated 2; Microphthalmia, Isolated, With Coloboma 3
Research Articles on VSX2
1. marker for neurogenic potential in cultured retinal progenitor cells
Precautions
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Disclaimer
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