Full Product Name
PREPL, CT (PREPL, KIAA0436, Prolyl endopeptidase-like, Prolylendopeptidase-like)
Product Synonym Names
Anti -PREPL, CT (PREPL, KIAA0436, Prolyl endopeptidase-like, Prolylendopeptidase-like)
Product Gene Name
anti-PREPL antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (44544746..44589001, complement). Location: 2p21
3D Structure
ModBase 3D Structure for Q4J6C6
Species Reactivity
Hamster, Human, Mouse
Specificity
Human, hamster, mouse
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
PREPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 631-660 amino acids from the C-terminal region of human PREPL.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-PREPL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PREPL antibody
The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome.
Product Categories/Family for anti-PREPL antibody
Antibodies; Abs to KIAA, orf
Applications Tested/Suitable for anti-PREPL antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PREPL antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
NCBI/Uniprot data below describe general gene information for PREPL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001165088.1
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NCBI GenBank Nucleotide #
NM_001171617.1
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UniProt Primary Accession #
Q4J6C6
[Other Products]
UniProt Secondary Accession #
O43163; Q4J6C3; Q4J6C4; Q4ZG39; Q6ZMW7; Q96DW7; A7E2X6; D6W5A3[Other Products]
UniProt Related Accession #
Q4J6C6[Other Products]
Molecular Weight
83,927 Da[Similar Products]
NCBI Official Full Name
prolyl endopeptidase-like isoform 4
NCBI Official Synonym Full Names
prolyl endopeptidase-like
NCBI Official Symbol
PREPL [Similar Products]
NCBI Protein Information
prolyl endopeptidase-like; putative prolyl oligopeptidase
UniProt Protein Name
Prolyl endopeptidase-like
UniProt Synonym Protein Names
Prolylendopeptidase-like
Protein Family
Prolyl endopeptidase
UniProt Gene Name
PREPL [Similar Products]
UniProt Synonym Gene Names
KIAA0436 [Similar Products]
UniProt Entry Name
PPCEL_HUMAN
NCBI Summary for PREPL
The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.[provided by RefSeq, Jan 2010]
UniProt Comments for PREPL
PREPL: Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Defects in PREPL are a cause of hypotonia-cystinuria syndrome (HCS). HCS is characterized generalized hypotonia at birth, nephrolithiasis, growth hormone deficiency, minor facial dysmorphism, failure to thrive, followed by hyperphagia and rapid weight gain in late childhood. HCS is caused by a deletion that disrups both SLC3A1 and PREPL genes. As SLC3A1 is known to cause isolated cystinuria type I, the extended phenotype could be attributed to the deletion of PREPL. Belongs to the peptidase S9A family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.21.-
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: Golgi apparatus; cytoskeleton; cytosol
Molecular Function: serine-type endopeptidase activity
Biological Process: proteolysis
Disease: Hypotonia-cystinuria Syndrome
Research Articles on PREPL
1. Two novel deletions encompassing the SLC3A1 and PREPL genes have been identified in unrelated hypotonia-cystinuria syndrome patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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