Gephyrin (GPHN), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of GPHN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9363831 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Gephyrin (GPHN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GPHN. The ELISA analytical biochemical technique of the MBS9363831 kit is based on GPHN antibody-GPHN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GPHN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GPHN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

83,448 Da

gephyrin

gephyrin

Gephyrin

GPH; KIAA1385; MPT adenylyltransferase; MPT Mo-transferase  [Similar Products]

GEPH_HUMAN

This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq, Jul 2008]

gephyrin: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. Homotrimer. Interacts with GABARAP. Inhibited by copper and tungsten. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75

Chromosomal Location of Human Ortholog: 14q23.3

Cellular Component: cell junction; cytoplasm; cytoskeleton; plasma membrane; postsynaptic membrane

Molecular Function: ATP binding; metal ion binding

Biological Process: establishment of synaptic specificity at neuromuscular junction; Mo-molybdopterin cofactor biosynthetic process; molybdenum incorporation into molybdenum-molybdopterin complex; molybdopterin cofactor biosynthetic process; vitamin metabolic process; water-soluble vitamin metabolic process

Disease: Hyperekplexia, Hereditary 1; Molybdenum Cofactor Deficiency, Complementation Group C

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