prolyl endopeptidase-like, ELISA Kit

Human Prolyl endopeptidase-like (PREPL) ELISA kit; FLJ16627; KIAA0436; OTTHUMP00000202420; OTTHUMP00000202421; OTTHUMP00000202424; OTTHUMP00000202425; OTTHUMP00000202426; putative prolyl oligopeptidase; prolyl endopeptidase-like

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of PREPL elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9330304 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the prolyl endopeptidase-like (PREPL) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PREPL. The ELISA analytical biochemical technique of the MBS9330304 kit is based on PREPL antibody-PREPL antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PREPL antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PREPL. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

83,927 Da

prolyl endopeptidase-like

prolyl endopeptidase-like; putative prolyl oligopeptidase

Prolyl endopeptidase-like

KIAA0436  [Similar Products]

PPCEL_HUMAN

The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.[provided by RefSeq, Jan 2010]

PREPL: Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Defects in PREPL are a cause of hypotonia-cystinuria syndrome (HCS). HCS is characterized generalized hypotonia at birth, nephrolithiasis, growth hormone deficiency, minor facial dysmorphism, failure to thrive, followed by hyperphagia and rapid weight gain in late childhood. HCS is caused by a deletion that disrups both SLC3A1 and PREPL genes. As SLC3A1 is known to cause isolated cystinuria type I, the extended phenotype could be attributed to the deletion of PREPL. Belongs to the peptidase S9A family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.-; Protease

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: Golgi apparatus; cytoskeleton; cytosol

Molecular Function: serine-type endopeptidase activity

Biological Process: proteolysis

Disease: Hypotonia-cystinuria Syndrome

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