ADRA1B, Polyclonal Antibody

Goat Anti-ADRA1B (aa252-264) Antibody; ADRA1B; adrenergic, alpha-1B-, receptor; ADRA1; ALPHA1BAR; OTTHUMP00000160844; alpha-1B adrenergic receptor; alpha-1B adrenoceptor; alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; ADRA1B antibody; adrenergic; alpha-1B-; receptor antibody; ADRA1 antibody; ALPHA1BAR antibody; OTTHUMP00000160844 antibody; alpha-1B adrenergic receptor antibody; alpha-1B adrenoceptor antibody; alpha-1B adrenoreceptor antibody; alpha-1B-adrenergic receptor antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-ADRA1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 55-60kDa band observed in Human, Mouse, Rat and Pig Heart lysates (calculated MW of 56.8kDa according to NP_000670.1). Recommended concentration: 0.1-0.3ug/ml.

(0.1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

(0.1ug/ml) staining of Pig Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

56,836 Da

adrenoceptor alpha 1B

alpha-1B adrenergic receptor

Alpha-1B adrenergic receptor

Alpha-1B adrenoceptor  [Similar Products]

ADA1B_HUMAN

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]

ADRA1B: a G protein-coupled catecholamine receptor that activates mitogenic responses and regulates growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. Can induce neoplastic transformation when transfected into cell lines. Can regulate the phosphorylation status of the STAT3 pathway. Mediates blood pressure and aorta contractile responses induced by alpha-1 agonists. Activates a phosphatidylinositol second messenger system.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: integral to plasma membrane; nuclear membrane; nucleus; plasma membrane

Molecular Function: alpha1-adrenergic receptor activity; protein heterodimerization activity

Biological Process: cell proliferation; cell-cell signaling; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); glucose homeostasis; multicellular organismal development; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; positive regulation of MAPKKK cascade; positive regulation of smooth muscle contraction; positive regulation of vasoconstriction

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