Full Product Name
DOK7 Antibody, FITC conjugated
Product Synonym Names
Protein Dok-7; Downstream of tyrosine kinase 7; DOK7; C4orf25
Product Gene Name
anti-DOK7 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q18PE1
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Protein Dok-7 protein (416-504AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-DOK7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DOK7 antibody
Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
Product Categories/Family for anti-DOK7 antibody
Signal transduction
Applications Tested/Suitable for anti-DOK7 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for DOK7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001158145.1
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NCBI GenBank Nucleotide #
NM_001164673.1
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UniProt Primary Accession #
Q18PE1
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UniProt Secondary Accession #
Q6P6A6; Q86XG5; Q8N2J3; Q8NBC1; A2A499; A2RRD4; E9PB56[Other Products]
UniProt Related Accession #
Q18PE1[Other Products]
Molecular Weight
63,938 Da
NCBI Official Full Name
protein Dok-7 isoform 2
NCBI Official Synonym Full Names
docking protein 7
NCBI Official Symbol
DOK7 [Similar Products]
NCBI Official Synonym Symbols
CMS10; CMS1B; C4orf25
[Similar Products]
NCBI Protein Information
protein Dok-7
UniProt Protein Name
Protein Dok-7
UniProt Synonym Protein Names
Downstream of tyrosine kinase 7
UniProt Gene Name
DOK7 [Similar Products]
UniProt Synonym Gene Names
C4orf25 [Similar Products]
NCBI Summary for DOK7
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
UniProt Comments for DOK7
Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
Research Articles on DOK7
1. DOK7 was reduced in lung cancer and reduced DOK7 expression was associated with poorer survival.DOK7 isoform 1 plays an inhibitory role on the proliferation and migration of lung cancer cells.
Precautions
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Disclaimer
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