Full Product Name
ARX antibody - middle region
Product Gene Name
anti-ARX antibody
[Similar Products]
Antibody/Peptide Pairs
ARX peptide (MBS3228289) is used for blocking the activity of ARX antibody (MBS3203319)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: ELSGPGGVAH PEERLSAASG PGSAPAAGGG TGAEDDEEEL LEDEEDEEEE
3D Structure
ModBase 3D Structure for O35085
Species Reactivity
Dog, Human, Mouse, Rat
Purity/Purification
Protein A purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Dog: 100%; Human: 93%; Mouse: 100%; Rat: 86%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of mouse ARX
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ARX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARX antibody
This is a rabbit polyclonal antibody against ARX. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: ARX (Aristaless-related genes), a subset of the Paired-related homeobox genes, is a group of regulators of essential events during vertebrate embryogenesis. Arx was highly conserved between mouse and zebrafish. Studies have disclosed its neuromeric expression in the forebrain and longitudinal expression in the floor plate in mouse and zebrafish. It is also expressed in the dorsal telencephalon (presumptive cerebral cortex) of mouse embryos.
Product Categories/Family for anti-ARX antibody
Polyclonal; Transcription Factor; Growth Factors & Hormones; Transcription Regulation; Developmental Biology; Neuroscience; Transcription Factors; Cell Differentiation;
Applications Tested/Suitable for anti-ARX antibody
Western Blot (WB)
Western Blot (WB) of anti-ARX antibody
WB Suggested Anti-ARX Antibody Titration: 5.0ug/ml
ELISA Titer: 1:1562500
Positive Control: NIH/3T3 cell lysate
NCBI/Uniprot data below describe general gene information for ARX. It may not necessarily be applicable to this product.
NCBI Accession #
NP_031518
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NCBI GenBank Nucleotide #
NM_007492
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UniProt Primary Accession #
O35085
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UniProt Related Accession #
O35085[Other Products]
NCBI Official Full Name
homeobox protein ARX
NCBI Official Synonym Full Names
aristaless related homeobox
NCBI Official Symbol
Arx [Similar Products]
NCBI Official Synonym Symbols
Arx1
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NCBI Protein Information
homeobox protein ARX
UniProt Protein Name
Homeobox protein ARX
UniProt Synonym Protein Names
Aristaless-related homeobox
Protein Family
Aristaless-related homeobox protein
UniProt Gene Name
Arx [Similar Products]
UniProt Entry Name
ARX_MOUSE
NCBI Summary for ARX
This gene encodes a transcription factor that plays an important role in the development of forebrain. Male mice lacking this gene have smaller brains, olfactory bulbs and testes, and die within half a day after birth. Mice lacking this gene specifically in ganglionic eminence-derived neurons, including cortical interneurons, develop seizures. Mutations in this gene have been demonstrated to cause mouse phenotypes resembling human X-linked lissencephaly and cognitive disability with epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Research Articles on ARX
1. Study characterized the disturbances to cortical interneuron development in mice modeling the two most common ARX polyalanine expansion mutations in human. We found a consistent approximately 40-50% reduction of calbindin-positive interneurons, but not Stt+ or Cr+ interneurons, within the cortex of newborn hemizygous mice for both mutant strains compared to wildtype.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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