Product Name
Anion/Sugar Transporter (AST), Monoclonal Antibody
Full Product Name
Botin-Linked Monoclonal Antibody to Anion/Sugar Transporter (AST)
Product Gene Name
anti-AST antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: Anion/Sugar Transporter (AST) (MBS2111307)
Biotin Conjugated Antibody: Anion/Sugar Transporter (AST) (MBS2110195)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NRA2
Specificity
The antibody is a mouse monoclonal antibody raised against AST. It has been selected for its ability to recognize AST in immunohistochemical staining and western blotting.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
500ug/ml (lot specific)
Preparation and Storage
Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Avoid repeated freeze/thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Other Notes
Small volumes of anti-AST antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-AST antibody
Signal Transduction
Applications Tested/Suitable for anti-AST antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
NCBI/Uniprot data below describe general gene information for AST. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036566
[Other Products]
NCBI GenBank Nucleotide #
NM_012434.5
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UniProt Primary Accession #
Q9NRA2
[Other Products]
UniProt Related Accession #
Q9NRA2[Other Products]
NCBI Official Full Name
sialin
NCBI Official Synonym Full Names
solute carrier family 17 member 5
NCBI Official Symbol
SLC17A5 [Similar Products]
NCBI Official Synonym Symbols
SD; AST; NSD; SLD; ISSD; SIASD; SIALIN
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NCBI Protein Information
sialin
UniProt Protein Name
Sialin
UniProt Synonym Protein Names
H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular H(+)/Aspartate-glutamate cotransporter
Protein Family
Allatostatin
UniProt Gene Name
SLC17A5 [Similar Products]
UniProt Synonym Gene Names
AST [Similar Products]
UniProt Entry Name
S17A5_HUMAN
NCBI Summary for AST
This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an ***** form. [provided by RefSeq, Jul 2008]
Research Articles on AST
1. study describes a novel pathogenic variant in SLC17A5, namely an intronic transposal insertion, in a patient with mild biochemical and clinical phenotypes. The presence of a small fraction of normal transcript may explain the mild phenotype. This case illustrates the importance of including lysosomal sialic acid storage disease in the differential diagnosis of developmental delay with postnatal onset and hypomyelination.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
