Full Product Name
DMPK Polyclonal Antibody
Product Gene Name
anti-DMPK antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q09013
Other Notes
Small volumes of anti-DMPK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DMPK. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001075029.1
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NCBI GenBank Nucleotide #
NM_001081560.2
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UniProt Primary Accession #
Q09013
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UniProt Secondary Accession #
Q16205; Q6P5Z6; E5KR08[Other Products]
UniProt Related Accession #
Q09013[Other Products]
Molecular Weight
60,790 Da
NCBI Official Full Name
myotonin-protein kinase isoform 3
NCBI Official Synonym Full Names
DM1 protein kinase
NCBI Official Symbol
DMPK [Similar Products]
NCBI Official Synonym Symbols
DM; DM1; DMK; MDPK; DM1PK; MT-PK
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NCBI Protein Information
myotonin-protein kinase
UniProt Protein Name
Myotonin-protein kinase
UniProt Synonym Protein Names
DM-kinase; DMK; DM1 protein kinase; DMPK; Myotonic dystrophy protein kinase
Protein Family
Myotonin-protein kinase
UniProt Gene Name
DMPK [Similar Products]
UniProt Synonym Gene Names
DM1PK; MDPK; MT-PK; DMK [Similar Products]
NCBI Summary for DMPK
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016]
UniProt Comments for DMPK
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
Research Articles on DMPK
1. A second point is that DM mutations, although located in noncoding regions, may reduce the expression of mutant alleles, raising questions whether loss-of-function may contribute to the phenotype, or possibly impose a safety limit on knockdown therapies that create or aggravate a DMPK or CNBP deficiency state
Precautions
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Disclaimer
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