Catenin, delta 2, Monoclonal Antibody

Anti -Catenin, delta 2 (Neural Plakophilin-related ARM-repeat Protein, NPRAP, Neurojungin, GT24, CTNND2)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 5; NC_000005.9 (10971952..11904110, complement). Location: 5p15.2

Monoclonal

IgG

9G331

Mouse

Recognizes human Catenin delta 2. Species Crossreactivity: mouse and rat.

Affinity Purified
Purified by affinity chromatography.

Supplied as a lyophilized powder in PBS, pH7.2. Reconstitute with 100ul sterile ddH2O.

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-CTNND2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Catenin delta-2 functions as a transcriptional activator when bound to ZBTB33. It may also be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. It is predominantly expressed in the brain and localises to the nucleus and cell junction. The unprocessed precursor has a length of 1225 amino acids and a predicted molecular weight of 132.7KDa. This protein is O-glycosylated. It is also phosporylated upon DNA damage. It belongs to the beta-catenin family and contains nine ARM repeats.

Antibodies; Abs to Plakophilin

Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in Immunohistochemistry and Western Blot.

132,656 Da[Similar Products]

catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)

catenin delta-2; neurojungin; OTTHUMP00000115594; OTTHUMP00000220687; OTTHUMP00000220689; OTTHUMP00000220690; T-cell delta-catenin

Catenin delta-2

NPRAP  [Similar Products]

CTND2_HUMAN

This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.

CTNND2: Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33. Binds to PSEN1. Interacts with RGNEF. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Predominantly expressed in brain; accumulates in cortical neurons. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5p15.2

Cellular Component: adherens junction; cytoplasm; perikaryon; nucleus

Molecular Function: protein binding

Biological Process: cell-cell adhesion; regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development; regulation of synaptic plasticity; morphogenesis of a branching structure; learning; cell adhesion; signal transduction

Disease: Cri-du-chat Syndrome

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