CRLF1, Polyclonal Antibody

Cytokine receptor-like factor 1; Cytokine-like factor 1; CLF-1; ZcytoR5; CRLF1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This CRLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-283 amino acids from the Central region of human CRLF1.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-CRLF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the cytokine type I receptor
family. The protein forms a secreted complex with
cardiotrophin-like cytokine factor 1 and acts on cells expressing
ciliary neurotrophic factor receptors. The complex can promote
survival of neuronal cells. Mutations in this gene result in
Crisponi syndrome and cold-induced sweating syndrome. [provided by
RefSeq].

Immunology

Western Blot (WB), ELISA (EIA)

WB~~1:1000

CRLF1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CRLF1 antibody detected the CRLF1 protein (arrow).

46302

cytokine receptor-like factor 1

cytokine receptor-like factor 1

Cytokine receptor-like factor 1

CLF-1  [Similar Products]

CRLF1_HUMAN

This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]

CRLF1: Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development. Defects in CRLF1 are the cause of cold-induced sweating syndrome type 1 (CISS1). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Defects in CRLF1 are the cause of Crisponi syndrome (CRISPS). Crisponi syndrome is a rare autosomal recessive disorder characterized by congenital muscular contractions of facial muscles, with trismus in response to stimuli, dysmorphic features, bilateral camptodactyly, major feeding and respiratory difficulties, and access of hyperthermia leading to death in the first months of life. Belongs to the type I cytokine receptor family. Type 3 subfamily.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: extracellular space

Molecular Function: protein binding; protein heterodimerization activity; cytokine binding; cytokine activity; receptor activity; ciliary neurotrophic factor receptor binding

Biological Process: ureteric bud development; positive regulation of cell proliferation; negative regulation of neuron apoptosis; positive regulation of tyrosine phosphorylation of Stat3 protein

Disease: Cold-induced Sweating Syndrome 1

Tsuritani, K., et al. Calcif. Tissue Int. 86(1):47-57(2010)
Crisponi, L., et al. Am. J. Hum. Genet. 80(5):971-981(2007)
Dagoneau, N., et al. Am. J. Hum. Genet. 80(5):966-970(2007)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Heese, K., et al. J. Cell. Biochem. 91(5):1030-1042(2004)

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