Product Name
CTNND2, Polyclonal Antibody
Full Product Name
CTNND2 Polyclonal Antibody
Product Synonym Names
GT24; NPRAP
Product Gene Name
anti-CTNND2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UQB3
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human CTNND2
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CTNND2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CTNND2 antibody
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Product Categories/Family for anti-CTNND2 antibody
Primary antibody
Applications Tested/Suitable for anti-CTNND2 antibody
Western Blot (WB)
Application Notes for anti-CTNND2 antibody
WB: 1:1000 - 1:3000
Western Blot (WB) of anti-CTNND2 antibody
Western blot analysis of extracts of PC-12 cells, using CTNND2 antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
NCBI/Uniprot data below describe general gene information for CTNND2. It may not necessarily be applicable to this product.
NCBI Accession #
Q9UQB3.3
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UniProt Primary Accession #
Q9UQB3
[Other Products]
UniProt Secondary Accession #
O00379; O15390; O43206; O43840; Q13589; Q9UM66; Q9UPM3; B0FTZ7[Other Products]
UniProt Related Accession #
Q9UQB3[Other Products]
NCBI Official Full Name
Catenin delta-2
NCBI Official Synonym Full Names
catenin delta 2
NCBI Official Symbol
CTNND2 [Similar Products]
NCBI Official Synonym Symbols
GT24; NPRAP
[Similar Products]
NCBI Protein Information
catenin delta-2
UniProt Protein Name
Catenin delta-2
UniProt Synonym Protein Names
Delta-catenin; GT24; Neural plakophilin-related ARM-repeat protein; NPRAP; Neurojungin
UniProt Gene Name
CTNND2 [Similar Products]
UniProt Synonym Gene Names
NPRAP; NPRAP [Similar Products]
NCBI Summary for CTNND2
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
UniProt Comments for CTNND2
CTNND2: Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33. Binds to PSEN1. Interacts with RGNEF. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Predominantly expressed in brain; accumulates in cortical neurons. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5p15.2
Cellular Component: cytoplasm; perikaryon
Molecular Function: beta-catenin binding; protein binding
Biological Process: cell adhesion; signal transduction; synapse organization and biogenesis
Disease: Cri-du-chat Syndrome
Research Articles on CTNND2
1. Our data suggested that genetic variants in GRM6 are associated with high myopia. The mechanism of GRM6 in the development of high myopia need to be further investigated.
Precautions
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Disclaimer
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