CRLF1, Polyclonal Antibody

Rabbit Polyclonal (IgG) to Human CRLF1; Human CRLF1; CISS1; Cytokine-like factor 1; CISS; CLF; CLF-1; NR6; Zcytor5; Class I cytokine receptor

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Human CRLF1

Immunoaffinity purified

0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal

1 mg/ml (lot specific)

Keep as concentrated solution. Aliquot and store at -20 degree C or below. Avoid multiple freeze-thaw cycles.

Small volumes of anti-CRLF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CRLF1 Antibody, CISS1 Antibody, Cytokine-like factor 1 Antibody, CISS Antibody, CLF Antibody, CLF-1 Antibody, NR6 Antibody, Zcytor5 Antibody, Class I cytokine receptor Antibody Description: Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P (7.5 ug/ml)
WB (1:500 - 1:3000)

Anti-CRLF1 antibody IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CRLF1 antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 7.5 ug/ml.

Sample (30 ug of whole cell lysate). A: Hep G2. 10% SDS PAGE. CRLF1 antibody diluted at 1:3000

46,302 Da

cytokine receptor-like factor 1

cytokine receptor-like factor 1

Cytokine receptor-like factor 1

CLF-1  [Similar Products]

CRLF1_HUMAN

This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]

CRLF1: Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development. Defects in CRLF1 are the cause of cold-induced sweating syndrome type 1 (CISS1). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Defects in CRLF1 are the cause of Crisponi syndrome (CRISPS). Crisponi syndrome is a rare autosomal recessive disorder characterized by congenital muscular contractions of facial muscles, with trismus in response to stimuli, dysmorphic features, bilateral camptodactyly, major feeding and respiratory difficulties, and access of hyperthermia leading to death in the first months of life. Belongs to the type I cytokine receptor family. Type 3 subfamily.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: extracellular region; extracellular space

Molecular Function: ciliary neurotrophic factor receptor binding; cytokine activity; cytokine binding; protein binding; protein heterodimerization activity; receptor activity

Biological Process: negative regulation of neuron apoptosis; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of Stat3 protein; ureteric bud development

Disease: Cold-induced Sweating Syndrome 1

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