Full Product Name
ATGL Antibody
Product Synonym Names
PNPLA2; Adipose triglyceride lipase; ATGL; IPLA2zeta; PEDF-R; IPLA2-zeta; Triglyceride hydrolase; TTS-2.2; TTS2; Transport-secretion protein 2; TTS2.2; Desnutrin; FP17548
Product Gene Name
anti-ATGL antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96AD5
Species Reactivity
Human, Mouse
Specificity
ATGL Antibody detects endogenous levels of total ATGL
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human ATGL
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ATGL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ATGL antibody
Total protein Ab
Applications Tested/Suitable for anti-ATGL antibody
Western Blot (WB)
Application Notes for anti-ATGL antibody
Western Blot: 1:1000-3000
Western Blot (WB) of anti-ATGL antibody
Western blot analysis ATGL using HuvEc whole cell lysates
NCBI/Uniprot data below describe general gene information for ATGL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_065109.1
[Other Products]
NCBI GenBank Nucleotide #
NM_020376.3
[Other Products]
UniProt Primary Accession #
Q96AD5
[Other Products]
UniProt Secondary Accession #
O60643; Q5EFF5; Q6XYE5; Q96ET6; Q9NQ61; Q9NQ62[Other Products]
UniProt Related Accession #
Q96AD5[Other Products]
Molecular Weight
19,875 Da
NCBI Official Full Name
patatin-like phospholipase domain-containing protein 2
NCBI Official Synonym Full Names
patatin like phospholipase domain containing 2
NCBI Official Symbol
PNPLA2 [Similar Products]
NCBI Official Synonym Symbols
ATGL; TTS2; PEDF-R; FP17548; TTS-2.2; iPLA2zeta; 1110001C14Rik
[Similar Products]
NCBI Protein Information
patatin-like phospholipase domain-containing protein 2
UniProt Protein Name
Patatin-like phospholipase domain-containing protein 2
UniProt Synonym Protein Names
Adipose triglyceride lipase; Calcium-independent phospholipase A2; Desnutrin; IPLA2-zeta; Pigment epithelium-derived factor; TTS2.2; Transport-secretion protein 2; TTS2
UniProt Gene Name
PNPLA2 [Similar Products]
UniProt Synonym Gene Names
ATGL; TTS2 [Similar Products]
UniProt Entry Name
PLPL2_HUMAN
NCBI Summary for ATGL
This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010]
UniProt Comments for ATGL
PNPLA2: the rate-limiting lipolytic enzyme in mammals, flies, and yeast. Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Upregulated by exercise training in human skeletal muscle. Has acylglycerol transacylase activity. May act coordinately with HSL within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Interacting with ABHD5 stimulates its triglyceride hydrolase activity. Despite a colocalization in lipid droplets, it probably does not interact with perilipin. Transcriptionally regulated by FOXO1A. Defects cause neutral lipid storage disease (NLSD), an autosomal recessive disorder characterized by the excessive accumulation of neutral lipids in multiple tissues. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.1.3; Lipase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytoplasm; endoplasmic reticulum membrane; lipid particle; membrane
Molecular Function: acylglycerol O-acyltransferase activity; lipoprotein lipase activity; triacylglycerol lipase activity
Biological Process: lipid homeostasis
Disease: Neutral Lipid Storage Disease With Myopathy
Research Articles on ATGL
1. A missense mutation in PNPLA2 is the rare cause of severe dilated cardiomyopathy secondary to neutral lipid storage disease.
Precautions
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Disclaimer
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