Full Product Name
Anti-SDHB Antibody
Product Synonym Names
SDH; SDH1; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip
Product Gene Name
anti-SDHB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P21912
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of SDHB protein.
Purity/Purification
Purified by immunogen affinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human SDHB
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-SDHB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SDHB antibody
Rabbit polyclonal antibody to SDHB
Applications Tested/Suitable for anti-SDHB antibody
Western Blot (WB)
Application Notes for anti-SDHB antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-SDHB antibody
Western blot analysis of SDHB expression in HepG2 (A), Hela (B), mouse heart (C), rat liver (D), rat brain (E) whole cell lysates.
NCBI/Uniprot data below describe general gene information for SDHB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002991.2
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NCBI GenBank Nucleotide #
NM_003000.2
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UniProt Primary Accession #
P21912
[Other Products]
UniProt Secondary Accession #
Q0QEY7; Q9NQ12; B2R545[Other Products]
UniProt Related Accession #
P21912[Other Products]
Molecular Weight
31,630 Da
NCBI Official Full Name
succinate dehydrogenase
NCBI Official Synonym Full Names
succinate dehydrogenase complex iron sulfur subunit B
NCBI Official Symbol
SDHB [Similar Products]
NCBI Official Synonym Symbols
IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
[Similar Products]
NCBI Protein Information
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
UniProt Protein Name
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
UniProt Synonym Protein Names
Iron-sulfur subunit of complex II; Ip
Protein Family
Succinate dehydrogenase
UniProt Gene Name
SDHB [Similar Products]
UniProt Synonym Gene Names
SDH; SDH1; Ip [Similar Products]
NCBI Summary for SDHB
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
UniProt Comments for SDHB
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Research Articles on SDHB
1. SDHB mutation is associated with metastatic pheochromocytoma.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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