Full Product Name
IKAP, Affinity Purified Antibody, Rabbit
Product Gene Name
anti-IKAP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Form/Format
Affinity Purified - Liquid
Immunogen
C terminus of IKAP
Other Notes
Small volumes of anti-IKAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IKAP antibody
The transcription factor NF-kappa B coordinates the activation of numerous genes in response to pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of acute and chronic inflammatory diseases. NF-kappa B is activated by cytokine-activated IKB kinases (IKKs); IKK-alpha and IKK-beta isozymes are found in large complexes. Theses large, interleukin-1-inducible IKK complexes have been found to contain a new protein, termed IKK-complex-associated protein (IKAP), which can bind NIK and IKKs and assemble them into an active kinase complex. IKAP is a scaffold protein and a regulator for 3 different kinases involved in pro-inflammatory cytokine signaling.
Product Categories/Family for anti-IKAP antibody
IKAP
Applications Tested/Suitable for anti-IKAP antibody
Western Blot (WB)
Testing Data of anti-IKAP antibody
Image: Western blot of IKAP (1:500) in HEK293 cells stimulated with interleukin-1
NCBI/Uniprot data below describe general gene information for IKAP. It may not necessarily be applicable to this product.
NCBI Accession #
AAC64258.1
[Other Products]
UniProt Secondary Accession #
Q5JSV2; Q9H327; Q9UG87[Other Products]
UniProt Related Accession #
O95163[Other Products]
Molecular Weight
150,254 Da
NCBI Official Full Name
IkappaB kinase complex associated protein
NCBI Official Synonym Full Names
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
NCBI Official Symbol
IKBKAP [Similar Products]
NCBI Official Synonym Symbols
FD; DYS; ELP1; IKAP; IKI3; TOT1
[Similar Products]
NCBI Protein Information
elongator complex protein 1
UniProt Protein Name
Elongator complex protein 1
UniProt Synonym Protein Names
IkappaB kinase complex-associated protein; IKK complex-associated protein; p150
UniProt Gene Name
IKBKAP [Similar Products]
UniProt Synonym Gene Names
ELP1; IKAP; ELP1; IKK complex-associated protein [Similar Products]
UniProt Entry Name
ELP1_HUMAN
NCBI Summary for IKAP
The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. [provided by RefSeq, Jul 2008]
UniProt Comments for IKAP
IKBKAP: May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3. Belongs to the ELP1/IKA1 family.
Protein type: Transcription regulation; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 9q31
Cellular Component: transcription elongation factor complex; Elongator holoenzyme complex; cytoplasm; nucleolus; histone acetyltransferase complex
Molecular Function: protein binding; signal transducer activity; phosphorylase kinase regulator activity
Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; RNA elongation from RNA polymerase II promoter; immune response; protein complex assembly; signal transduction; regulation of protein kinase activity; protein amino acid phosphorylation; positive regulation of cell migration
Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iii
Research Articles on IKAP
1. IKBKAP mRNA levels decreased during a familial dysautonomia crisis and returned to baseline after recovery. The cause-and-effect relationship is unclear.
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