Product Name
Acrosin heavy chain, Blocking Peptide
Full Product Name
Acrosin heavy chain Immunizing Peptide
Product Synonym Names
ACR; acrosin; acrosin light and heavy chain prepropeptide; preproacrosin; proacrosin; Acrosin heavy chain; Acrosin heavy chain
Product Gene Name
ACR blocking peptide
[Similar Products]
Acrosin heavy chain peptide (MBS428078) is used for blocking the activity of Acrosin heavy chain antibody (MBS423391)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Dog
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of ACR blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ACR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001088.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001097.2
[Other Products]
UniProt Secondary Accession #
Q6ICK2[Other Products]
UniProt Related Accession #
P10323[Other Products]
Molecular Weight
45,847 Da
NCBI Official Full Name
acrosin
NCBI Official Synonym Full Names
acrosin
NCBI Official Symbol
ACR [Similar Products]
NCBI Protein Information
acrosin
UniProt Protein Name
Acrosin
UniProt Gene Name
ACR [Similar Products]
UniProt Synonym Gene Names
ACRS [Similar Products]
UniProt Entry Name
ACRO_HUMAN
NCBI Summary for ACR
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]
UniProt Comments for ACR
ACR: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Belongs to the peptidase S1 family.
Protein type: EC 3.4.21.10; Protease
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: acrosomal matrix; extracellular region; Golgi-associated vesicle; nucleus; protein complex
Molecular Function: amidase activity; copper ion binding; DNA binding; drug binding; fucose binding; mannose binding; protease binding; protein binding; serine-type endopeptidase activity; zinc ion binding
Biological Process: acrosome matrix dispersal; acrosome reaction; adenylate cyclase activation; binding of sperm to zona pellucida; penetration of zona pellucida; response to steroid hormone stimulus; single fertilization
Research Articles on ACR
1. Data indicate that the positive expression of studied genes fertilization rate for GAPDHS positive subset was 66%, ACR - 71%, SPATA22 - 68%, MND1 - 70%, pregnancy rates were 8%, 6%, 18% and 36% respectively.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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