FGFRL1, Polyclonal Antibody

FHFR; FGFR5

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

1mg/mL (lot specific)

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-FGFRL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.

ELISA (EIA), Immunohistochemistry (IHC)

IHC: 1:25-1:100

Immunohistochemistry of paraffin-embedded Human colon cancer tissue using FGFRL1 Polyclonal Antibody at dilution 1:20

Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using FGFRL1 Polyclonal Antibody at dilution 1:20

54,537 Da

fibroblast growth factor receptor-like 1

fibroblast growth factor receptor-like 1; FGF homologous factor receptor; FGF receptor-like protein 1; FGFR-5; FGFR-like protein; fibroblast growth factor receptor 5

Fibroblast growth factor receptor-like 1

FGFR5; FHFR; FGF receptor-like protein 1; FGFR-5  [Similar Products]

FGRL1_HUMAN

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

FGFRL1: Has a negative effect on cell proliferation.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p16

Cellular Component: Golgi apparatus; transport vesicle; integral to membrane; plasma membrane

Molecular Function: heparin binding; fibroblast growth factor binding; fibroblast growth factor receptor activity

Biological Process: negative regulation of cell proliferation; fibroblast growth factor receptor signaling pathway; protein heterooligomerization; skeletal development; protein homooligomerization

Disease: Wolf-hirschhorn Syndrome

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