Full Product Name
FUCA1 Antibody, HRP conjugated
Product Synonym Names
Tissue alpha-L-fucosidase; Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1; Alpha-L-fucosidase 1; FUCA1; Nbla10230
Product Gene Name
anti-FUCA1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P04066
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Tissue alpha-L-fucosidase protein (32-158AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-FUCA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FUCA1 antibody
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1, 6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Applications Tested/Suitable for anti-FUCA1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for FUCA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000138.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000147.4
[Other Products]
UniProt Primary Accession #
P04066
[Other Products]
UniProt Secondary Accession #
Q14334; Q14335; Q3LID0; Q8NAC2; B2RBG3[Other Products]
UniProt Related Accession #
P04066[Other Products]
Molecular Weight
53,689 Da
NCBI Official Full Name
tissue alpha-L-fucosidase
NCBI Official Synonym Full Names
fucosidase, alpha-L- 1, tissue
NCBI Official Symbol
FUCA1 [Similar Products]
NCBI Official Synonym Symbols
FUCA
[Similar Products]
NCBI Protein Information
tissue alpha-L-fucosidase
UniProt Protein Name
Tissue alpha-L-fucosidase
UniProt Synonym Protein Names
Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1; Alpha-L-fucosidase 1
Protein Family
Tissue alpha-L-fucosidase
UniProt Gene Name
FUCA1 [Similar Products]
UniProt Synonym Gene Names
Alpha-L-fucosidase 1 [Similar Products]
NCBI Summary for FUCA1
The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009]
UniProt Comments for FUCA1
FUCA1: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins. Defects in FUCA1 are the cause of fucosidosis (FUCA1D). FUCA1D is an autosomal recessive lysosomal storage disease characterized by accumulation of fucose-containing glycolipids and glycoproteins in various tissues. Clinical signs include facial dysmorphism, dysostosis multiplex, moderate hepatomegaly, severe intellectual deficit, deafness, and according to age, angiokeratomas. Belongs to the glycosyl hydrolase 29 family.
Protein type: EC 3.2.1.51; Glycan Metabolism - other glycan degradation; Hydrolase
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: cytoplasm; lysosomal lumen
Molecular Function: alpha-L-fucosidase activity
Biological Process: fucose metabolic process; glycoside catabolic process
Disease: Fucosidosis
Research Articles on FUCA1
1. results show that protein defucosylation mediated by FUCA1 is involved in tumor suppression
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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