Product Name
Phosphoserine Phosphatase (PSPH), Monoclonal Antibody
Full Product Name
Phosphoserine Phosphatase, Human (PSP, HPSP PSPase)
Product Synonym Names
Anti -Phosphoserine Phosphatase, Human (PSP, HPSP PSPase)
Product Gene Name
anti-PSPH antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 7; NC_000007.13 (56078744..56119268, complement). Location: 7p11.2
3D Structure
ModBase 3D Structure for P78330
Specificity
Recognizes human phosphoserine phosphatase
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
Immunogen
Recombinant human PSP (1-225aa) (E. coli)
Hybridoma
Sp2/0 myeloma cells with spleen cells from Balb/c mice.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-PSPH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PSPH antibody
Human phosphoserine phosphatase (HPSP), specific for D- and L- phosphoserine, has been
Product Categories/Family for anti-PSPH antibody
Antibodies; Abs to Enzymes, Phosphatase
Applications Tested/Suitable for anti-PSPH antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PSPH antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:2000
NCBI/Uniprot data below describe general gene information for PSPH. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004568.2
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NCBI GenBank Nucleotide #
NM_004577.3
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UniProt Primary Accession #
P78330
[Other Products]
UniProt Secondary Accession #
Q7Z3S5; B2RCR5[Other Products]
UniProt Related Accession #
P78330; Q53EY1[Other Products]
Molecular Weight
25,008 Da[Similar Products]
NCBI Official Full Name
phosphoserine phosphatase
NCBI Official Synonym Full Names
phosphoserine phosphatase
NCBI Official Symbol
PSPH [Similar Products]
NCBI Official Synonym Symbols
PSP; PSPHD
[Similar Products]
NCBI Protein Information
phosphoserine phosphatase; PSPase; OTTHUMP00000159738; OTTHUMP00000209319; OTTHUMP00000209324; OTTHUMP00000209327; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase
UniProt Protein Name
Phosphoserine phosphatase
UniProt Synonym Protein Names
L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase
Protein Family
Phosphoserine phosphatase
UniProt Gene Name
PSPH [Similar Products]
UniProt Entry Name
SERB_HUMAN
NCBI Summary for PSPH
The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq]
UniProt Comments for PSPH
PSPH: Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome. Belongs to the SerB family.
Protein type: Hydrolase; EC 3.1.3.3; Amino Acid Metabolism - glycine, serine and threonine; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7p11.2
Cellular Component: neuron projection; cytoplasm; cytosol
Molecular Function: protein homodimerization activity; phosphoserine phosphatase activity; magnesium ion binding; calcium ion binding
Biological Process: response to nutrient levels; L-serine biosynthetic process; dephosphorylation; response to mechanical stimulus; L-serine metabolic process; response to testosterone stimulus; amino acid biosynthetic process
Disease: Phosphoserine Phosphatase Deficiency
Research Articles on PSPH
1. human phosphoserine phosphatase structure now shows a sevenfold coordinated Ca(2+) ion in the active site that might explain the inhibitory effect of Ca(2+) on the enzyme
Precautions
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Disclaimer
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