Product Name
D(4) dopamine receptor (Drd4), Recombinant Protein
Full Product Name
Recombinant Mouse D (4) dopamine receptor (Drd4)
Product Gene Name
Drd4 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-387. Full length.
Sequence
MGNSSATEDG GLLAGRGPES LGTGAGLGGA GAAALVGGVL LIGLVLAGNS LVCVSVASER TLQTPTNYFI VSLAAADLLL AVLVLPLFVY SEVQGGVWLL SPRLCDTLMA MDVMLCTASI FNLCAISVDR FVAVTVPLRY NQQGQCQLLL IAATWLLSAA VASPVVCGLN DVPGRDPAVC CLENRDYVVY SSVCSFFLPC PLMLLLYWAT FRGLRRWEAA RHTKLHSRAP RRPSGPGPPV SDPTQGPFFP DCPPPLPSLR TSPSDSSRPE SELSQRPCSP GCLLADAALP QPPEPSSRRR RGAKITGRER KAMRVLPVVV GAFLVCWTPF FVVHITRALC PACFVSPRLV SAVTWLGYVN SALNPIIYTI FNAEFRSVFR KTLRLRC
3D Structure
ModBase 3D Structure for P51436
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Drd4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Drd4 recombinant protein
Transmembrane Protein
Application Notes for Drd4 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Drd4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_031904.1
[Other Products]
NCBI GenBank Nucleotide #
NM_007878.2
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UniProt Primary Accession #
P51436
[Other Products]
UniProt Secondary Accession #
O35838; Q7TT80; Q8BXS4[Other Products]
UniProt Related Accession #
P51436[Other Products]
Molecular Weight
41,487 Da
NCBI Official Full Name
D(4) dopamine receptor
NCBI Official Synonym Full Names
dopamine receptor D4
NCBI Official Symbol
Drd4 [Similar Products]
NCBI Official Synonym Symbols
D4R; Drd-4; AW125663
[Similar Products]
NCBI Protein Information
D(4) dopamine receptor
UniProt Protein Name
D(4) dopamine receptor
UniProt Synonym Protein Names
D(2C) dopamine receptor; Dopamine D4 receptor
Protein Family
D(4) dopamine receptor
UniProt Gene Name
Drd4 [Similar Products]
UniProt Entry Name
DRD4_MOUSE
UniProt Comments for Drd4
DRD4: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Cellular Component: axon; cell cortex; cell soma; cytoplasm; dendrite; dendritic spine; integral to membrane; integral to plasma membrane; membrane; nerve terminal; plasma membrane; terminal button; vesicle membrane
Molecular Function: dopamine binding; dopamine D1 receptor-like receptor activity; dopamine D2 receptor-like receptor activity; dopamine receptor activity; drug binding; G-protein coupled receptor activity; identical protein binding; SH3 domain binding; signal transducer activity
Biological Process: activation of MAPK activity; ***** locomotory behavior; arachidonic acid secretion; associative learning; behavioral fear response; behavioral response to cocaine; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase inhibiting pathway; fear response; G-protein coupled receptor protein signaling pathway; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of protein secretion; olfactory learning; positive regulation of kinase activity; positive regulation of sodium:hydrogen antiporter activity; regulation of calcium-mediated signaling; regulation of circadian rhythm; regulation of dopamine metabolic process; regulation of inhibitory postsynaptic membrane potential; regulation of neurotransmitter secretion; regulation of synaptic transmission; response to amphetamine; rhythmic process; short-term memory; signal transduction; synaptic transmission, dopaminergic
Research Articles on Drd4
1. This study demonstrated that dopamine D4 receptor gene has an important role in increased exploratory and anxiolytic behavior only in males and these behaviors were positively correlated with increased alcohol consumption.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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