Anion Exchanger 2, Polyclonal Antibody

Anti -Anion Exchanger 2 (AE2)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 7; NC_012598.1 (148744152..148761392). Location: chromosome: 7

Polyclonal

IgG

Rabbit

Recognizes rat AE-2. Species sequence homology: mouse- 100%, rabbit-90%, human-85%, chicken-80%.

Serum
Serum

Supplied as a liquid in PBS and 0.05% sodium azide, 40% glycerol.

May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-SLC4A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Anion exchangers (AE) are membranes proteins involved in the regulation of intracellular pH, cell volume regulation as well as in transepithelial acid/base transport. AE proteins are sodium-independent exchangers that mediates one-for-one exchange of extracellular Cl- for intracellular HCO3- ions resulting in intracellular acidification. AE proteins are encoded by a family of at least three related genes (AE1, AE2, and AE3). Numerous alternatively spliced isoforms of each AE gene are expressed in various tissues. AE proteins are exemplified by a large N-terminal cytoplasmic domain (~40-75kD) that provides s for cytoskeleton protein, glycolytic enzymes and hemoglobin. The N-terminal cytoplasmic domains of AE2 are AE3 are more closely related than AE1. In fact, AE1 N-terminus is 300 aa shorter than both the AE2 and AE3. The C-terminal TM domain (~55kD) is highly conserved (~70% identity) among various AE, spans the lipid bilayer 12-14 times, and is able to mediate anion exchange by itself.

Antibodies; Abs to Ion Channel

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:5000
ELISA: 1:10,000-50,000

136,799 Da[Similar Products]

anion exchange protein 2; AE 2; anion exchanger 2; solute carrier family 4 member 2

Anion exchange protein 2

AE2; AE 2  [Similar Products]

B3A2_PONAB

Function: Plasma membrane anion exchange protein of wide distribution

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

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