CD59, Polyclonal Antibody

Rabbit Polyclonal (IgG) to Human CD59; Human CD59; 16.3A5; 1F5; 1F5 antigen; CD59 glycoprotein; EL32; EJ16; G344; HRF-20; MAC-IP; MACIF; Ly-6-like protein; MEM43; MIRL; MEM43 antigen; MIN2; MIN3; MSK21; p18-20; Protectin; MAC-inhibitory protein; MIC11; T cell-activating protein; CD59 antigen

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Human CD59

Immunoaffinity purified

PBS, 0.02% sodium azide.

1 mg/ml (lot specific)

Long term: -20 degree C
Short term: 4 degree C
Avoid repeat freeze-thaw cycles

Small volumes of anti-CD59 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CD59 Antibody, 16.3A5 Antibody, 1F5 Antibody, 1F5 antigen Antibody, CD59 glycoprotein Antibody, EL32 Antibody, EJ16 Antibody, G344 Antibody, HRF-20 Antibody, MAC-IP Antibody, MACIF Antibody, Ly-6-like protein Antibody, MEM43 Antibody, MIRL Antibody, MEM43 antigen Antibody, MIN2 Antibody, MIN3 Antibody, MSK21 Antibody, p18-20 Antibody, Protectin Antibody, MAC-inhibitory protein Antibody, MIC11 Antibody, T cell-activating protein Antibody, CD59 antigen Antibody, EJ30 Antibody, HRF20 Antibody, Human leukocyte antigen MIC11 Antibody, Lymphocytic antigen CD59/MEM43 Antibody, MIN1 Antibody Description: CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)

IHC-P (10 ug/ml)
WB (1 - 2 ug/ml)

Anti-CD59 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CD59 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Western blot analysis of CD59 in mouse spleen tissue lysate with CD59 antibody at 1 ug/ml

14,177 Da

CD59 molecule

CD59 glycoprotein

CD59 glycoprotein

MIC11; MIN1; MIN2; MIN3; MSK21; HRF-20; HRF20; MAC-IP; MACIF; MIRL  [Similar Products]

CD59_HUMAN

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

CD59: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: anchored to external side of plasma membrane; cell surface; compact myelin; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; extracellular space; focal adhesion; Golgi membrane; membrane; plasma membrane; sarcolemma; vesicle

Molecular Function: complement binding; protein binding

Biological Process: blood coagulation; cell surface receptor linked signal transduction; cellular protein metabolic process; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; innate immune response; negative regulation of activation of membrane attack complex; negative regulation of apoptosis; positive regulation of T cell proliferation; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; regulation of complement activation

Disease: Hemolytic Anemia, Cd59-mediated, With Or Without Immune-mediated Polyneuropathy

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