Full Product Name
EFEMP1 Antibody
Product Synonym Names
EGF-containing fibulin-like extracellular matrix protein 1; Fibulin-3; FIBL-3; Fibrillin-like protein; Extracellular protein S1-5
Product Gene Name
anti-EFEMP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q12805
Species Reactivity
Human, Mouse, Rat
Specificity
EFEMP1 antibody detects endogenous levels of total EFEMP1 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human EFEMP1.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-EFEMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-EFEMP1 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-EFEMP1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-EFEMP1 antibody
WB: 1:500-1:1000
ELISA: 1:10000
Western Blot (WB) of anti-EFEMP1 antibody
Western blot analysis of extracts from rat lung cells, using EFEMP1 antibody.
NCBI/Uniprot data below describe general gene information for EFEMP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001034437.1
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NCBI GenBank Nucleotide #
NM_001039348.2
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UniProt Primary Accession #
Q12805
[Other Products]
UniProt Secondary Accession #
Q541U7; A8K3I4; B4DW75; D6W5D2[Other Products]
UniProt Related Accession #
Q12805[Other Products]
Molecular Weight
39,195 Da
NCBI Official Full Name
EGF-containing fibulin-like extracellular matrix protein 1
NCBI Official Synonym Full Names
EGF containing fibulin extracellular matrix protein 1
NCBI Official Symbol
EFEMP1 [Similar Products]
NCBI Official Synonym Symbols
DHRD; DRAD; FBNL; MLVT; MTLV; S1-5; FBLN3; FIBL-3
[Similar Products]
NCBI Protein Information
EGF-containing fibulin-like extracellular matrix protein 1
UniProt Protein Name
EGF-containing fibulin-like extracellular matrix protein 1
UniProt Synonym Protein Names
Extracellular protein S1-5; Fibrillin-like protein; Fibulin-3; FIBL-3
Protein Family
EGF-containing fibulin-like extracellular matrix protein
UniProt Gene Name
EFEMP1 [Similar Products]
UniProt Synonym Gene Names
FBLN3; FBNL; FIBL-3 [Similar Products]
NCBI Summary for EFEMP1
This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009]
UniProt Comments for EFEMP1
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
Product References and Citations for anti-EFEMP1 antibody
Lecka-Czernik B., Mol. Cell. Biol. 15:120-128(1995). Ikegawa S., Genomics 35:590-592(1996). Giltay R., Matrix Biol. 18:469-480(1999).
Research Articles on EFEMP1
1. This study found a nominally different distribution of EFEMP1 genotypes, alleles and haplotypes between suicidal subjects and controls.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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