Product Name
2-hydroxyisobutyryl-HIST1H1C, Polyclonal Antibody
Full Product Name
2-hydroxyisobutyryl-HIST1H1C (K80) Antibody
Product Synonym Names
Histone H1.2; Histone H1c; Histone H1d; Histone H1s-1; HIST1H1C; H1F2
Product Gene Name
anti-HIST1H1C antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P16403
Purity/Purification
Antigen Affinity Purified
Immunogen
Peptide sequence around site of 2-hydroxyisobutyryl-Lys (80) derived from Human Histone H1.2
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at-20 degree C or-80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-HIST1H1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-HIST1H1C antibody
Epigenetics and Nuclear Signaling
Applications Tested/Suitable for anti-HIST1H1C antibody
ELISA (EIA), Chromatin Immunoprecipitation (ChIP)
Chromatin Immunoprecipitation (ChIP) of anti-HIST1H1C antibody
Chromatin Immunoprecipitation Hela (10
6, treated with 30mM sodium butyrate for 4h) were treated with Micrococcal Nuclease, sonicated, and immunoprecipitated with 5ug anti-HIST1H1C (CSB-PA010378OA80hibHU) or a control normal rabbit IgG. The resulting ChIP DNA was quantified using real-time PCR with primers against the beta-Globin promoter.
NCBI/Uniprot data below describe general gene information for HIST1H1C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005310.1
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NCBI GenBank Nucleotide #
NM_005319.3
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UniProt Primary Accession #
P16403
[Other Products]
UniProt Secondary Accession #
A8K4I2[Other Products]
UniProt Related Accession #
P16403[Other Products]
Molecular Weight
21,365 Da
NCBI Official Full Name
histone H1.2
NCBI Official Synonym Full Names
histone cluster 1 H1 family member c
NCBI Official Symbol
HIST1H1C [Similar Products]
NCBI Official Synonym Symbols
H1C; H1.2; H1F2; H1s-1
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NCBI Protein Information
histone H1.2
UniProt Protein Name
Histone H1.2
UniProt Synonym Protein Names
Histone H1c; Histone H1d; Histone H1s-1
UniProt Gene Name
HIST1H1C [Similar Products]
UniProt Synonym Gene Names
H1F2 [Similar Products]
NCBI Summary for HIST1H1C
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
UniProt Comments for HIST1H1C
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation ().
Research Articles on HIST1H1C
1. results define a network of E2F target genes as susceptible to the regulatory influence of H1.2, where H1.2 augments global association of pRb with chromatin, enhances transcriptional repression by pRb, and facilitates pRb-dependent cell-cycle arrest
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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