GRIN2A, Polyclonal Antibody

Polyclonal GRIN2A; Anti-GRIN2A; GRIN 2A; GRIN-2A; GRIN2A; Glutamate Receptor Ionotropic N-Methyl D-Aspartate 2A; NMDAR2A; NR2A

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

GRIN2A antibody was purified by affinity chromatography

Supplied in liquid form in 10 mM HEPES buffer (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol

Small volumes of anti-GRIN2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal GRIN2A antibody (N-terminus)

Signal Transduction; Purified Polyclonal Antibodies

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:1000
IHC: 1:500

Immunofluorescent staining of 21 DIV nucleofected mouse striatal neuron (green) co-cultured with cortical neurons showing nice punctate labeling of the N-terminal NR2A subunit (red) in both the medium spiny neurons and the large pyramidal cell in the upper right

Western blot of 10 ug of rat hippocampal lysate showing specific immunolabeling of ~ 180k NR2A subunit.

144,431 Da

glutamate receptor, ionotropic, N-methyl D-aspartate 2A

glutamate receptor ionotropic, NMDA 2A

Glutamate receptor ionotropic, NMDA 2A

NMDAR2A; GluN2A; NMDAR2A; NR2A; hNR2A  [Similar Products]

NMDE1_HUMAN

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

NMDAR2A: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 16p13.2

Cellular Component: presynaptic membrane; postsynaptic membrane; synaptic vesicle; cell surface; integral to plasma membrane; endoplasmic reticulum; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; zinc ion binding; calcium channel activity; N-methyl-D-aspartate selective glutamate receptor activity

Biological Process: startle response; positive regulation of apoptosis; regulation of synaptic plasticity; sensory perception of pain; dopamine metabolic process; synaptic transmission; protein localization; learning and/or memory; transport; response to wounding; visual learning; serotonin metabolic process; response to drug; synaptic transmission, glutamatergic; glutamate signaling pathway; response to amphetamine; sleep; memory; response to ethanol; neurogenesis; directional locomotion; ionotropic glutamate receptor signaling pathway; regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential; negative regulation of protein catabolic process

Disease: Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation

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