GRIN2A / NMDAR2A / NR2A, Polyclonal Antibody

Rabbit Polyclonal to Rat GRIN2A / NMDAR2A / NR2A; Rat GRIN2A / NMDAR2A / NR2A; GRIN2A; EPND; HNR2A; GluN2A; GluR epsilon 1; NMDA receptor 2A; NMDAR2A; NR2A; NMDA receptor subtype 2A

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Specific for the ~180k NR2A subunit of the NMDA receptor

Immunoaffinity purified

10 mM HEPES, pH 7.5, 150 mM sodium chloride, 100 ug per ml BSA, 50% glycerol.

Long term: -20 degree C
Short term: -20 degree C

Small volumes of anti-GRIN2A / NMDAR2A / NR2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

GRIN2A Antibody, EPND Antibody, HNR2A Antibody, GluN2A Antibody, GluR epsilon 1 Antibody, NMDA receptor 2A Antibody, NMDAR2A Antibody, NR2A Antibody, NMDA receptor subtype 2A Antibody Description: GRIN2A / NMDAR2A / NR2A is a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P (1:100)
WB (1:1000)

Rat Brain: Formalin-Fixed, Paraffin-Embedded (FFPE)

Western blot of 10 ug of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2A subunit of the NMDA receptor.

144,431 Da

glutamate ionotropic receptor NMDA type subunit 2A

glutamate receptor ionotropic, NMDA 2A

Glutamate receptor ionotropic, NMDA 2A

NMDAR2A; GluN2A; NMDAR2A; NR2A; hNR2A  [Similar Products]

NMDE1_HUMAN

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

NMDAR2A: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p13.2

Cellular Component: cell junction; cell surface; endoplasmic reticulum; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic membrane; presynaptic membrane; synaptic vesicle

Molecular Function: calcium channel activity; extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; protein binding; zinc ion binding

Biological Process: activation of MAPKK activity; axon guidance; directional locomotion; dopamine metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; glutamate signaling pathway; innate immune response; insulin receptor signaling pathway; ionotropic glutamate receptor signaling pathway; learning and/or memory; MAPKKK cascade; memory; negative regulation of protein catabolic process; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; protein localization; Ras protein signal transduction; regulation of excitatory postsynaptic membrane potential; regulation of sensory perception of pain; response to amphetamine; response to drug; response to ethanol; response to wounding; sensory perception of pain; serotonin metabolic process; sleep; small GTPase mediated signal transduction; startle response; synaptic transmission; transport; vascular endothelial growth factor receptor signaling pathway; visual learning

Disease: Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation

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