Basic Fibroblast Growth Factor, Reagent

For Research Use Only. Not for use in diagnostic procedures.

Small volumes of r-bFGF reagent vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Human basic Fibroblast Growth Factor (bFGF) is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of angiogenesis. bFGF has been shown to support the maintenance of undifferentiated human embryonic stem cells. It also stimulates the proliferation of all cells of mesodermal origin, and many cells of neuroectodermal, ectodermal and endodermal origin. bFGF is a chemotactic and mitogenic agent for endothelial cells in vitro and induces neural differentiation, survival and regeneration. It has been shown to be crucial in modulation of angiogenesis, tissue repair, embryonic development and neuronal function in vivo.
Human embryonic stem cell and various other stem cell line such as mesenchymal stem (stroma) cell (MSC) culture

Reagents and Buffer

Human embryonic stem cell and various other stem cell line such as mesenchymal stem (stroma) cell (MSC) culture

21,203 Da

fibroblast growth factor 2

fibroblast growth factor 2

Fibroblast growth factor 2

FGFB; FGF-2; bFGF; HBGF-2  [Similar Products]

FGF2_HUMAN

FGF2: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation.

Protein type: Activator; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q26

Cellular Component: extracellular region; extracellular space

Molecular Function: 1-phosphatidylinositol-3-kinase activity; chemoattractant activity; cytokine activity; fibroblast growth factor receptor binding; growth factor activity; ligand-dependent nuclear receptor transcription coactivator activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: activation of MAPK activity; cell migration during sprouting angiogenesis; chemotaxis; embryonic morphogenesis; extracellular matrix organization and biogenesis; fibroblast growth factor receptor signaling pathway; growth factor dependent regulation of satellite cell proliferation; hyaluronan catabolic process; inositol phosphate biosynthetic process; MAPKKK cascade; negative regulation of blood vessel endothelial cell migration; nervous system development; organ morphogenesis; phosphatidylinositol biosynthetic process; phosphoinositide-mediated signaling; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cardiac muscle cell proliferation; positive regulation of cell fate specification; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of phosphoinositide 3-kinase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; regulation of angiogenesis; regulation of phosphoinositide 3-kinase cascade; release of sequestered calcium ion into cytosol; somatic stem cell maintenance; ureteric bud branching; wound healing

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