Amiloride-sensitive cation channel 1, neuronal (ACCN1), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of ACCN1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS7249072 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Amiloride-sensitive cation channel 1, neuronal (ACCN1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACCN1. The ELISA analytical biochemical technique of the MBS7249072 kit is based on ACCN1 antibody-ACCN1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACCN1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACCN1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Neurobiology

62,887 Da

acid-sensing (proton-gated) ion channel 2

acid-sensing ion channel 2; brain sodium channel 1; mammalian degenerin homolog; neuronal amiloride-sensitive cation channel 1; amiloride-sensitive cation channel 1, neuronal

Acid-sensing ion channel 2

ACCN; ACCN1; BNAC1; MDEG; ASIC2; BNC1; BNaC1  [Similar Products]

ASIC2_HUMAN

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]

ASIC2: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Apoptosis; Membrane protein, integral; Transporter; Channel, cation; Transporter, ion channel

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cell soma; integral to plasma membrane; plasma membrane; dendritic spine; synapse

Molecular Function: amiloride-sensitive sodium channel activity; protein binding; ion gated channel activity; voltage-gated sodium channel activity

Biological Process: central nervous system development; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; monovalent inorganic cation transport; sensory perception of sour taste; detection of mechanical stimulus involved in sensory perception; peripheral nervous system development; positive regulation of synaptogenesis; synaptic transmission; regulation of membrane potential; sensory perception of sound; regulation of gene expression; regulation of vasoconstriction; regulation of blood coagulation; phototransduction; transmembrane transport; negative regulation of apoptosis

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