Product Name
Glycogen Synthase (GYS), Polyclonal Antibody
Popular Item
Full Product Name
Glycogen Synthase Antibody
Product Synonym Names
Glycogen [starch] synthase; Glycogen synthase 1 (muscle); Glycogen synthase 1; GSY; Gys1; GYS1_HUMAN; muscle
Product Gene Name
anti-GYS antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P13807
Species Reactivity
Human, Mouse, Rat
Predicted: Pig, Zebrafish, Bovine, Sheep, Rabbit, Dog
Specificity
Glycogen Synthase Antibody detects endogenous levels of Glycogen Synthase.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human Glycogen Synthase.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-GYS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GYS antibody
Description: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Post Translational Modifications: Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme.
Subunit Structure: Interacts with GYG1.
Similarity: Belongs to the glycosyltransferase 3 family.
Applications Tested/Suitable for anti-GYS antibody
Western Blot (WB), Peptide ELISA (EIA)
Application Notes for anti-GYS antibody
WB: 1:500-1:2000
ELISA (Peptide): 1:20000-1:40000
Western Blot (WB) of anti-GYS antibody
Western blot analysis of Glycogen Synthase in lysates of NIH-3T3 , using Glycogen Synthase Antibody.
NCBI/Uniprot data below describe general gene information for GYS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001155059.1
[Other Products]
NCBI GenBank Nucleotide #
NP_001155059.1
[Other Products]
UniProt Primary Accession #
P13807
[Other Products]
UniProt Related Accession #
P13807[Other Products]
Molecular Weight
Observed: 85 kDa
Predicted: 84 kDa
NCBI Official Full Name
glycogen
NCBI Official Synonym Full Names
glycogen synthase 1
NCBI Official Symbol
GYS1 [Similar Products]
NCBI Official Synonym Symbols
GSY; GYS
[Similar Products]
NCBI Protein Information
glycogen [starch] synthase, muscle
UniProt Protein Name
Glycogen [starch] synthase, muscle
Protein Family
Glycogen synthase
UniProt Gene Name
GYS1 [Similar Products]
UniProt Synonym Gene Names
GYS [Similar Products]
UniProt Entry Name
GYS1_HUMAN
NCBI Summary for GYS
The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Comments for GYS
GYS1: muscle glycogen synthase 1. Transfers glucosyl residue from UDP-glucose to glycogen. Regulated allosterically by glucose-6-phosphate, and by PKA-mediated phosphorylation.
Protein type: EC 2.4.1.11; Transferase; Carbohydrate Metabolism - starch and sucrose
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: membrane; cytoplasm; inclusion body; cytosol
Molecular Function: protein binding; glycogen (starch) synthase activity; protein kinase binding; glucose binding
Biological Process: glycogen biosynthetic process; heart development; carbohydrate metabolic process; glucose metabolic process; pathogenesis
Disease: Glycogen Storage Disease 0, Muscle
Research Articles on GYS
1. Insulin-stimulated glycogen synthase (GS) activity was completely ablated during hyperinsulinemic hypoglycemia, and catecholamine signaling via cAMP-dependent protein kinase (PKA) and phosphorylation of inhibiting sites on GS all increased.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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