Product Name
Glycogen Synthase (GYS), Antibody
Full Product Name
Phospho-Glycogen Synthase (Ser645) Antibody
Product Synonym Names
EC 2.4.1.11; glycogen [starch] synthase; muscle; glycogen synthase; muscle
Product Gene Name
anti-GYS antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P13807
Species Reactivity
Human, Mouse, Rat
Specificity
Phospho-Glycogen Synthase (Ser645) Antibody detects endogenous levels of Glycogen Synthase only when phosphorylated at Serine 645
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human Glycogen Synthase around the phosphorylation site of Serine 645
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-GYS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GYS antibody
GYS1 muscle glycogen synthase 1. Transfers glucosyl residue from UDP-glucose to glycogen. Regulated allosterically by glucose-6-phosphate, and by PKA-mediated phosphorylation.
Applications Tested/Suitable for anti-GYS antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GYS antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
Western Blot (WB) of anti-GYS antibody
Western blot analysis of Glycogen Synthase phosphorylation expression in PMA treated NIH-3T3 whole cell lysates, The lane on the left is treated with the antigen-specific peptide.

NCBI/Uniprot data below describe general gene information for GYS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001155059.1
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NCBI GenBank Nucleotide #
NM_001161587.1
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UniProt Primary Accession #
P13807
[Other Products]
UniProt Secondary Accession #
Q9BTT9[Other Products]
UniProt Related Accession #
P13807[Other Products]
Molecular Weight
83; 89kDa
NCBI Official Full Name
glycogen
NCBI Official Synonym Full Names
glycogen synthase 1
NCBI Official Symbol
GYS1 [Similar Products]
NCBI Official Synonym Symbols
GSY; GYS
[Similar Products]
NCBI Protein Information
glycogen [starch] synthase, muscle
UniProt Protein Name
Glycogen [starch] synthase, muscle
Protein Family
Glycogen synthase
UniProt Gene Name
GYS1 [Similar Products]
UniProt Synonym Gene Names
GYS [Similar Products]
NCBI Summary for GYS
The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Comments for GYS
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Research Articles on GYS
1. Insulin-stimulated glycogen synthase (GS) activity was completely ablated during hyperinsulinemic hypoglycemia, and catecholamine signaling via cAMP-dependent protein kinase (PKA) and phosphorylation of inhibiting sites on GS all increased.
Precautions
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Disclaimer
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