CNNM4, Polyclonal Antibody

Metal transporter CNNM4; Ancient conserved domain-containing protein 4; Cyclin-M4; CNNM4; ACDP4 KIAA1592

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>95%
Protein G Purified

Liquid

Upon receipt, store at-20 degree C or-80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-CNNM4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Neuroscience

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

IHC: 1:200-1:500
IF: 1:50-1:200

IHC image of CSB-PA764727LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA764727LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 degree C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

29,485 Da

cyclin and CBS domain divalent metal cation transport mediator 4

metal transporter CNNM4

Metal transporter CNNM4

ACDP4; KIAA1592  [Similar Products]

This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq, Feb 2010]

Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (). May play a role in biomineralization and retinal function.

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