retinitis pigmentosa 1 (autosomal dominant), ELISA Kit

Mouse Oxygen-regulated protein 1 (RP1) ELISA kit; DCDC4A; FLJ50293; FLJ55454; FLJ79410; ORP1; oxygen-regulated protein 1; retinitis pigmentosa RP1 protein; retinitis pigmentosa 1 (autosomal dominant)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of RP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9321635 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the retinitis pigmentosa 1 (autosomal dominant) (RP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing RP1. The ELISA analytical biochemical technique of the MBS9321635 kit is based on RP1 antibody-RP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, RP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

234,388 Da

retinitis pigmentosa 1 (human)

oxygen-regulated protein 1; retinitis pigmentosa 1 homolog; retinitis pigmentosa RP1 protein homolog

Oxygen-regulated protein 1

Orp1; Rp1h  [Similar Products]

RP1_MOUSE

This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Two transcript variants encoding distinct isoforms are resulted from alternative promoters and alternative splicing. [provided by RefSeq, Sep 2010]

ORP1: Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme. Defects in RP1 are the cause of retinitis pigmentosa type 1 (RP1). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Protein type: Receptor, misc.

Cellular Component: microtubule associated complex; cell projection; photoreceptor outer segment; photoreceptor inner segment; cytoskeleton; cytoplasm; axoneme; photoreceptor connecting cilium; cilium

Molecular Function: microtubule binding

Biological Process: photoreceptor cell development; retinal rod cell development; retinal cone cell development; visual perception; cell projection organization and biogenesis; retina development in camera-type eye; negative regulation of microtubule depolymerization; response to stimulus; photoreceptor cell maintenance; retina morphogenesis in camera-type eye; microtubule polymerization; axoneme biogenesis

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