Product Name
Glycogen Synthase (Phospho-Ser645) (GYS1), Antibody
Full Product Name
Rabbit Glycogen Synthase (Phospho-Ser645) Antibody
Product Gene Name
anti-GYS1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (49471382..49496610, complement). Location: 19q13.3
3D Structure
ModBase 3D Structure for P13807
Species Reactivity
Human, mouse, rat
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-GYS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GYS1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for GYS1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001155059.1
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NCBI GenBank Nucleotide #
NM_001161587.1
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UniProt Primary Accession #
P13807
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UniProt Secondary Accession #
Q9BTT9[Other Products]
UniProt Related Accession #
P13807[Other Products]
Molecular Weight
83,786 Da[Similar Products]
NCBI Official Full Name
glycogen
NCBI Official Synonym Full Names
glycogen synthase 1 (muscle)
NCBI Official Symbol
GYS1 [Similar Products]
NCBI Official Synonym Symbols
GSY; GYS
[Similar Products]
NCBI Protein Information
glycogen [starch] synthase, muscle; glycogen [starch] synthase, muscle
UniProt Protein Name
Glycogen [starch] synthase, muscle
Protein Family
Glycogen [starch] synthase
UniProt Gene Name
GYS1 [Similar Products]
UniProt Synonym Gene Names
GYS [Similar Products]
UniProt Entry Name
GYS1_HUMAN
NCBI Summary for GYS1
The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Comments for GYS1
GYS1: muscle glycogen synthase 1. Transfers glucosyl residue from UDP-glucose to glycogen. Regulated allosterically by glucose-6-phosphate, and by PKA-mediated phosphorylation.
Protein type: Transferase; Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: membrane; cytoplasm; inclusion body; cytosol
Molecular Function: protein binding; glycogen (starch) synthase activity; protein kinase binding; glucose binding
Biological Process: glycogen biosynthetic process; heart development; carbohydrate metabolic process; glucose metabolic process; pathogenesis
Disease: Glycogen Storage Disease 0, Muscle
Research Articles on GYS1
1. Data suggest that although COOH-terminal dephosphorylation is likely necessary for GS activation, protein kinase Akt-2- (Akt2)-dependent NH2-terminal dephosphorylation is site for "fine-tuning" insulin-mediated GS activation in skeletal muscle.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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