killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail,

Rat Killer cell immunoglobulin-like receptor 2DS2 (KIR2DS2) ELISA kit; CU464060.1; 183ActI; CD158J; CD158b; MGC120018; MGC120020; MGC149477; MGC149478; NKAT5; cl-49; 1060P11.9.2; NK receptor; killer-cell Ig-like receptor; natural killer associated transcript 5; natural kil; killer cell immunoglobulin-like receptor; two domains; short cytoplasmic tail; 2

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of KIR2DS2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9310883 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 (KIR2DS2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KIR2DS2. The ELISA analytical biochemical technique of the MBS9310883 kit is based on KIR2DS2 antibody-KIR2DS2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KIR2DS2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KIR2DS2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

33,502 Da

killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2

killer cell immunoglobulin-like receptor 2DS2; NK receptor 183 ActI; MHC class I NK cell receptor; killer-cell Ig-like receptor; CD158 antigen-like family member J; natural killer associated transcript 5; natural killer cell inhibitory receptor; p58 killer cell inhibitory receptor KIR-K7a; p58 natural killer cell receptor clone CL-49; killer-cell immunoglobulin-like receptor two domains short tail 2 protein

Killer cell immunoglobulin-like receptor 2DS2

CD158J; NKAT5; NKAT-5; p58 NK receptor CL-49  [Similar Products]

KI2S2_HUMAN

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene represents a haplotype-specific family member that encodes a protein with a short cytoplasmic tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

KIR2DS2: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamily.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: plasma membrane; integral to membrane

Molecular Function: transmembrane receptor activity

Biological Process: regulation of immune response; innate immune response; immune response; signal transduction

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