Full Product Name
CBP Antibody: ATTO 594
Product Synonym Names
Rabbit Anti-Human CBP Polyclonal; RSTS Antibody; CBP_HUMAN Antibody; Cyclic AMP responsive enhancer binding protein Antibody; Crebbp Antibody; CREB-binding protein Antibody; Rubinstein Taybi syndrome Antibody; KAT3A Antibody; EC:2.3.1.48 Antibody; CREBBP Antibody; CBP Antibody; RTS Antibody; CREB binding protein Antibody
Product Gene Name
anti-CBP antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: CBP (MBS8000949)
ATTO 594 Conjugated Antibody: CBP (MBS8000953)
Matching Pairs
Unconjugated Antibody: N/A (MBS8000953)
ATTO 594 Conjugated Antibody: CBP (MBS8000953)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q92793
Specificity
Detects 265 kDa.
Purity/Purification
Peptide Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthetic peptide from the mid-protein of Human CBP (aa. 1000-1100)
Cellular Localization
Cytoplasm; Nucleus
Storage Buffer
PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide
Preparation and Storage
Store at -20 degree C.
Other Notes
Small volumes of anti-CBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CBP antibody
Antibodies; Cell Signaling; Epigenetics and Nuclear Signaling; Chromatin Modifying Enzymes; Transcription; Stem Cells; Signaling Pathways; Wnt / Beta Catenin Pathway; Cancer; Cancer Metabolism; Cancer Lipid and Lipoprotein Metabolism; Cancer; Cancer Metab
Applications Tested/Suitable for anti-CBP antibody
Western Blot (WB)
Application Notes for anti-CBP antibody
WB: 1:1000
Western Blot (WB) of anti-CBP antibody
Western blot analysis of Human Cervical cancer cell line (HeLa) lysate showing detection of ~265.3 kDa CBP protein using Rabbit Anti-CBP Polyclonal Antibody (SPC-751). Lane 1: Molecular Weight Ladder (MW). Lane 2: HeLa. Load: 10 ug. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-CBP Polyclonal Antibody (SPC-751) at 1:1000 for 2 hours at RT. Secondary Antibody: Goat Anti-Rabbit IgG: HRP at 1:4000 for 1 hour at RT. Color Development: ECL solution for 5 min at RT. Predicted/Observed Size: ~265.3 kDa.
NCBI/Uniprot data below describe general gene information for CBP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001073315.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001079846.1
[Other Products]
UniProt Primary Accession #
Q92793
[Other Products]
UniProt Secondary Accession #
O00147; Q16376; Q4LE28; D3DUC9[Other Products]
UniProt Related Accession #
Q92793[Other Products]
Molecular Weight
260,993 Da
NCBI Official Full Name
CREB-binding protein isoform b
NCBI Official Synonym Full Names
CREB binding protein
NCBI Official Symbol
CREBBP [Similar Products]
NCBI Official Synonym Symbols
CBP; RSTS; KAT3A; RSTS1
[Similar Products]
NCBI Protein Information
CREB-binding protein
UniProt Protein Name
CREB-binding protein
Protein Family
CBP3-like protein
UniProt Gene Name
CREBBP [Similar Products]
UniProt Synonym Gene Names
CBP [Similar Products]
NCBI Summary for CBP
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
UniProt Comments for CBP
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902).
Research Articles on CBP
1. Our study demonstrated the association of low CREBBP expression with adverse clinical and
biological features, poor prednisone response, high MRD levels and inferior outcomes in paediatric Chinese patients with ALL who were treated with the BCH- 2003 and CCLG- 2008 pro- tocols.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
